Characteristics and Clinical Value of 18F-FDG PET/CT in the Management of Adult-Onset Still’s Disease: 35 Cases

Autor: Martin Killian, Anne-Laure Fauchais, Josselin Brisset, Yvan Jamilloux, Pascal Sève, Guillaume Gondran, Stéphanie Dumonteil, Tomasz Chroboczek, Kim Heang Ly, Mathieu Gerfaud-Valentin, Guillaume Lades, Jacques Monteil, Eric Liozon, Anne Lemaire
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Journal of Clinical Medicine
Volume 10
Issue 11
Journal of Clinical Medicine, Vol 10, Iss 2489, p 2489 (2021)
ISSN: 2077-0383
DOI: 10.3390/jcm10112489
Popis: While the diagnosis of adult-onset Still’s disease (AOSD) involves the exclusion of differential diagnoses, the characteristics and value of 18F-Fluorodeoxyglucose (18F-FDG) Positron Emission Tomography coupled with CT (PET/CT) in the management of AOSD remain poorly known. Our retrospective study included patients from four centers, fulfilling Yamaguchi or Fautrel criteria, who underwent a PET/CT during an active AOSD. Thirty-five patients were included. At the time of PET/CT, the Yamaguchi criteria were met in 23 of 29 evaluable cases. PET/CT showed bone marrow (74.3%), lymph node (74.3%), and splenic (48.6%) FDG uptake. Despite arthralgia or arthritis in most patients, joints were rarely the sites of 18F-FDG accumulation. The spatial distribution of 18F-FDG uptake was nonspecific, and its intensity could be similar to malignant disease. Lymph node or bone marrow biopsy was performed after PET/CT in 20 patients (57.1%). The intensity of bone marrow
splenic and lymph node hypermetabolism appeared to be correlated with disease activity. Abnormal PET/CT in the cervical lymph nodes and age ≥ 60 years seemed to be predictive factors for monocyclic evolution. The clinical value of PET/CT is not in direct diagnosis
but as an aid in excluding differential diagnoses by searching for their scintigraphic features and guiding biopsy.
Databáze: OpenAIRE
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