The significance of enhancer of zeste homolog 2 (EZH2) expression in spindle cell lesions of the breast
| Autor: | Eugene Santagada, Kayla Hackman, Doaa Morrar, Sabina Hajiyeva, Cao Jin, Iskender Sinan Genco |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Adult Pathology medicine.medical_specialty Metaplastic carcinoma Breast Neoplasms macromolecular substances Nodular fasciitis Fibroma Benign Phyllodes Tumor Pathology and Forensic Medicine Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Phyllodes Tumor Medicine Neurofibroma Humans Enhancer of Zeste Homolog 2 Protein Breast business.industry Fibromatosis Carcinoma Phyllodes tumor General Medicine Metaplastic Breast Carcinoma Middle Aged medicine.disease Immunohistochemistry 030104 developmental biology 030220 oncology & carcinogenesis Female business Myofibroblastoma |
| Zdroj: | Pathology internationalREFERENCES. 71(6) |
| ISSN: | 1440-1827 |
| Popis: | Spindle cell lesions of the breast are rare entities and pose a diagnostic challenge for pathologists due to overlapping morphologic and immunohistochemical features. We evaluated EZH2 expression in various benign (fibromatosis (n = 8), myofibroblastoma (n = 7), neurofibroma (n = 1), nodular fasciitis (n = 5), benign phyllodes tumor (n = 18)) and malignant (malignant phyllodes tumor (n = 8), metaplastic breast carcinoma (n = 16) and angiosarcoma (n = 8)) spindle cell lesions as a potential diagnostic and therapeutic marker. The EZH2 expression was evaluated semi-quantitatively to categorize the cases as 'low' and 'high' expression. All benign lesions showed low EZH2 expression, whereas high EZH2 expression was observed in the majority (28/32; 88%) of malignant lesions. The study results suggest that EZH2 may be used both as an additional diagnostic tool to reach an accurate diagnosis of the spindle cell lesions of the breast and as a therapeutic target for the malignant lesions. |
| Databáze: | OpenAIRE |
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