Evaluation of surgical anti-adhesion products to reduce postsurgical intra-abdominal adhesion formation in a rat model
| Autor: | Jing-Wan Luo, Yu Long Sun, Hui-Hui Zhang, Liao Nina, Long-Xiang Lin, Fang Yuan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Medical Doctors
Polymers Health Care Providers lcsh:Medicine Biocompatible Materials Tissue Adhesions 02 engineering and technology Abdominal wall Rats Sprague-Dawley Cecum chemistry.chemical_compound Glycols 0302 clinical medicine Postoperative Complications Abdomen Medicine and Health Sciences Hyaluronic Acid lcsh:Science Multidisciplinary Adhesion 021001 nanoscience & nanotechnology Professions Chemistry medicine.anatomical_structure Abdominal Surgery Macromolecules Polyethylene 030220 oncology & carcinogenesis Physical Sciences Female Anatomy 0210 nano-technology Research Article medicine.medical_specialty Materials by Structure Polyesters Sodium hyaluronate Materials Science Urology Surgical and Invasive Medical Procedures macromolecular substances 03 medical and health sciences Physicians PEG ratio medicine Animals Surgeons Chitosan Wound Healing business.industry Abdominal Wall lcsh:R Chemical Compounds Biology and Life Sciences Polymer Chemistry Surgery Rats Gastrointestinal Tract Health Care Disease Models Animal chemistry People and Places Population Groupings lcsh:Q business Wound healing Digestive System Abdominal surgery |
| Zdroj: | PLoS ONE, Vol 12, Iss 2, p e0172088 (2017) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Background Adhesions frequently occur after abdominal surgery. Many anti-adhesion products have been used in clinic. However, the evidences are short for surgeons to reasonably choose the suitable anti-adhesion produces in clinical practice. This study provided such evidence by comparing the efficiency of five products to prevent abdominal adhesion formation in a rat model. Methods Fifty-six Sprague-Dawley rats were randomly divided into seven groups: sham-operation group, adhesion group, and five product groups (n = 8). The abdomens of rats were opened. The injuries were created on abdominal wall and cecum in the adhesion and product groups. The wounds on abdominal wall and cecum of rats in the adhesion group were not treated before the abdomens were closed. The wounds on abdominal wall and cecum of rats in the product groups were covered with anti-adhesion product: polylactic acid (PLA) film, Seprafilm®, medical polyethylene glycol berberine liquid (PEG), medical sodium hyaluronate gel (HA), or medical chitosan (Chitosan). Fourteen days after surgery, the adhesions were evaluated by incidence, severity, adhesion area on abdominal wall and adhesion breaking strength. Results The application of PLA film and Seprafilm® significantly reduced the incidence, severity, adhesion area and breaking strength of cecum-abdomen adhesion (P0.05). The statistical significances in the incidence and severity of abdomen-adipose adhesion between adhesion group and the product groups were not achieved. However, Seprafilm® was more effective to reduce abdomen-adipose adhesion than PLA film. Furthermore, it was found that the products tested in this study did not effectively reduce cecum-adipose adhesion. The application of PEG could result in abdomen-small intestine adhesion. Conclusion Based on the results of this study, the preference order of anti-adhesion products used to reduce postsurgical intra-abdominal adhesion formation is Seprafilm > PLA >> HA > Chitosan > PEG. |
| Databáze: | OpenAIRE |
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