QA-RecombineIt: a server for quality assessment and recombination of protein models
| Autor: | Marcin Pawłowski, Janusz M. Bujnicki, Albert Bogdanowicz |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Models
Molecular Protein Conformation Phase problem Biology computer.software_genre Bioinformatics 03 medical and health sciences Software Protein structure Genetics 030304 developmental biology Internet 0303 health sciences business.industry Quality assessment 030302 biochemistry & molecular biology Articles Multiple input Protein Structure Tertiary Protein model The Internet Data mining User interface business computer Algorithms |
| Zdroj: | Nucleic Acids Research |
| ISSN: | 1362-4962 0305-1048 |
| Popis: | QA-RecombineIt provides a web interface to assess the quality of protein 3D structure models and to improve the accuracy of models by merging fragments of multiple input models. QA-RecombineIt has been developed for protein modelers who are working on difficult problems, have a set of different homology models and/or de novo models (from methods such as I-TASSER or ROSETTA) and would like to obtain one consensus model that incorporates the best parts into one structure that is internally coherent. An advanced mode is also available, in which one can modify the operation of the fragment recombination algorithm by manually identifying individual fragments or entire models to recombine. Our method produces up to 100 models that are expected to be on the average more accurate than the starting models. Therefore, our server may be useful for crystallographic protein structure determination, where protein models are used for Molecular Replacement to solve the phase problem. To address the latter possibility, a special feature was added to the QA-RecombineIt server. The QA-RecombineIt server can be freely accessed at http://iimcb.genesilico.pl/qarecombineit/. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|