Safety Assessment of Conventional and Biological Systemic Therapy in Older Adults with Psoriasis, a Real-world Multicentre Cohort Study
| Autor: | Elke L.M. Ter Haar, Eline E. Ten Bruin, Ewald E. Bronkhorst, Rinke J. Borgonjen, Marloes M. Kleinpenning, Else N. Kop, M. Birgitte Visch, Peter C.M. Van de Kerkhof, Elke M.G.J. De Jong, Satish F.K. Lubeek |
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| Rok vydání: | 2022 |
| Předmět: |
Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10]
Cohort Studies Cancer development and immune defence Radboud Institute for Health Sciences [Radboudumc 2] All institutes and research themes of the Radboud University Medical Center Incidence Inflammatory diseases Radboud Institute for Health Sciences [Radboudumc 5] Humans Psoriasis Dermatology General Medicine Dermatologic Agents Aged Retrospective Studies |
| Zdroj: | Acta Dermato-Venereologica, 102 |
| ISSN: | 1651-2057 0001-5555 |
| Popis: | Optimal selection of systemic therapy in older adults with psoriasis can be challenging, due to sparse evidence-based guidance. This multicentre retrospective study investigated the safety of systemic therapy with causality assessment in a real-world cohort of older adults (≥ 65 years) with psoriasis. Data from 6 hospitals on (serious) adverse events were collected, causality assessment performed and incidence rate ratios calculated. Potential predictors for adverse events-occurrence were studied using multivariable logistic regression analysis. In total, 117 patients with 176 treatment episodes and 390 patient-years were included, comprising 115 (65.3%) and 61 (34.7%) treatment episodes with conventional systemic therapy and biologics/apremilast, respectively. After causality assessment, 232 of 319 (72.7%) adverse events remained and were analysed further, including 12 serious adverse events. No significant differences in incidence rate ratios were found between the systemic treatment types. In regression analysis, increasing age was associated with causality assessed adverse events-occurrence (odds ratio 1.195; p=0.022). Comorbidity, polypharmacy, and treatment type were not associated with causality assessed adverse events-occurrence. In conclusion, increasing age was associated with a higher causality assessed adverse events-occurrence. Causality assessed serious adverse events were rare, reversible and/or manageable in clinical practice. In conclusion, the safety profile of systemic antipsoriatic therapy within this population is reassuring. |
| Databáze: | OpenAIRE |
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