Three new DP alleles identified in a study of 800 unrelated bone marrow donor-recipient pairs
| Autor: | Ann B. Begovich, Miriam Segall, Thomas M. Williams, Maurine L. Davidson, T. Winden, C. Moehlenkamp, S. Johnson, Harriet Noreen, Jin Wu, Lori Steiner, A. Cavalli |
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| Rok vydání: | 2002 |
| Předmět: |
HLA-DP Antigens
Immunology Molecular Sequence Data Biology HLA-DP alpha-Chains Biochemistry DNA sequencing Polymorphism (computer science) Sequence Homology Nucleic Acid Genetics Immunology and Allergy Humans Amino Acid Sequence Allele Genotyping Alleles HLA-DP beta-Chains Bone Marrow Transplantation Genetic diversity HLA-DPB1 Transition (genetics) Base Sequence Sequence Homology Amino Acid General Medicine Molecular biology Sequence motif |
| Zdroj: | Tissue antigens. 58(4) |
| ISSN: | 0001-2815 |
| Popis: | HLA-DP genotyping of 500 donor recipient pairs in a retrospective analysis sponsored by the National Marrow Donor Program (NMDP) identified four new DP alleles, two DPB1 and two DPA1 1. DNA sequencing confirmed that DPB1*8001 and *8101, each found in a single individual, are novel combinations of previously described sequence motifs in the six variable regions of DPB1. DPA1*02014, found in two individuals, is identical to DPA1*02011 except for a novel silent substitution, a G to A transition at the third position of codon 14. DPA1*01032, found in one individual, is identical to DPB1*01031 except for a silent G to A transition at the third position of codon 20. The identification of these novel alleles brings the total number of reported DPB1 alleles to 85 and DPA1 alleles to 15. |
| Databáze: | OpenAIRE |
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