Membrane lipidomics in schizophrenia patients: a correlational study with clinical and cognitive manifestations
| Autor: | Jonathan P. Roiser, A. Frajerman, Philippe Nuss, Kim Sweers, Nathanael Lapidus, Florian Ferreri, Catherine Delva, Haifa Bergaoui, Cedric Tessier, M. De Hert, Antonin Lamaziere |
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| Přispěvatelé: | Laboratoire des biomolécules (LBM UMR 7203), Chimie Moléculaire de Paris Centre (FR 2769), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Département de Chimie - ENS Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Sylia Stat Lancrenon S.A.S., Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Pierre et Marie Curie - Paris 6 (UPMC), Institute of Cognitive Neuroscience (ICN-UCL), University College of London [London] (UCL), INSERM-ERL 1157, CHU St Antoine, UPC-KU Leuven, Service de santé publique [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), HAL-UPMC, Gestionnaire |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Erythrocytes Dopamine Statistics as Topic [SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health Neuropsychological Tests Synaptic Transmission 0302 clinical medicine Wisconsin Card Sorting Test Phospholipids Positive and Negative Syndrome Scale Fatty Acids Middle Aged Sphingomyelins 3. Good health Psychiatry and Mental health Female Schizophrenic Psychology Original Article [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Psychopharmacology Sphingomyelin Psychology Signal Transduction Psychopathology medicine.drug Clinical psychology Adult medicine.medical_specialty Psychometrics Membrane Lipids 03 medical and health sciences Cellular and Molecular Neuroscience Internal medicine medicine Humans Dementia Cognitive Dysfunction [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Biological Psychiatry Case-control study Lipid Metabolism medicine.disease 030227 psychiatry Endocrinology Case-Control Studies [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health Chronic Disease Schizophrenia 030217 neurology & neurosurgery |
| Zdroj: | Translational Psychiatry Translational Psychiatry, 2016, 6 (10), pp.e906. ⟨10.1038/tp.2016.142⟩ Translational Psychiatry, Nature Pub. Group, 2016, 6 (10), pp.e906. ⟨10.1038/tp.2016.142⟩ Europe PubMed Central |
| ISSN: | 2158-3188 |
| DOI: | 10.1038/tp.2016.142⟩ |
| Popis: | Schizophrenia is a severe mental condition in which several lipid abnormalities—either structural or metabolic—have been described. We tested the hypothesis that an abnormality in membrane lipid composition may contribute to aberrant dopamine signaling, and thereby symptoms and cognitive impairment, in schizophrenia (SCZ) patients. Antipsychotic-medicated and clinically stable SCZ outpatients (n=74) were compared with matched healthy subjects (HC, n=40). A lipidomic analysis was performed in red blood cell (RBC) membranes examining the major phospholipid (PL) classes and their associated fatty acids (FAs). Clinical manifestations were examined using the positive and negative syndrome scale (PANSS). Cognitive function was assessed using the Continuous Performance Test, Salience Attribution Test and Wisconsin Card Sorting Test. Sphingomyelin (SM) percentage was the lipid abnormality most robustly associated with a schizophrenia diagnosis. Two groups of patients were defined. The first group (SCZ c/SM−) is characterized by a low SM membrane content. In this group, all other PL classes, plasmalogen and key polyunsaturated FAs known to be involved in brain function, were significantly modified, identifying a very specific membrane lipid cluster. The second patient group (SCZ c/SM+) was similar to HCs in terms of RBC membrane SM composition. Compared with SCZ c/SM+, SCZ c/SM− patients were characterized by significantly more severe PANSS total, positive, disorganized/cognitive and excited psychopathology. Cognitive performance was also significantly poorer in this subgroup. These data show that a specific RBC membrane lipid cluster is associated with clinical and cognitive manifestations of dopamine dysfunction in schizophrenia patients. We speculate that this membrane lipid abnormality influences presynaptic dopamine signaling. |
| Databáze: | OpenAIRE |
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