Advances in Molecular Tools and In Vivo Models for the Study of Human Fungal Pathogenesis
| Autor: | Jane Usher, Neil A. R. Gow, Dhara Malavia |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
Antifungal drug genetic tools Computational biology Disease Drug resistance Review Microbiology 03 medical and health sciences RNA interference Virology CRISPR lcsh:QH301-705.5 Zebrafish 030304 developmental biology 0303 health sciences biology 030306 microbiology fungi biology.organism_classification animal models Galleria mellonella lcsh:Biology (General) Infectious disease (medical specialty) RNAi fungal pathogens |
| Zdroj: | Microorganisms Microorganisms, Vol 8, Iss 803, p 803 (2020) |
| ISSN: | 2076-2607 |
| Popis: | Pathogenic fungi represent an increasing infectious disease threat to humans, especially with an increasing challenge of antifungal drug resistance. Over the decades, numerous tools have been developed to expedite the study of pathogenicity, initiation of disease, drug resistance and host-pathogen interactions. In this review, we highlight advances that have been made in the use of molecular tools using CRISPR technologies, RNA interference and transposon targeted mutagenesis. We also discuss the use of animal models in modelling disease of human fungal pathogens, focusing on zebrafish, the silkworm, Galleria mellonella and the murine model. |
| Databáze: | OpenAIRE |
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