Side-chain Modifications of Highly Functionalized 3(2H)-Furanones
| Autor: | Mauricio Gomes Constantino, Viviani Nardini, Shirley Muniz Machado Rodrigues, Gil Valdo José da Silva |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Alkylation
3(2H)-furanone Nitrile natural products Butanols Oxide Pharmaceutical Science Article Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound lcsh:Organic chemistry Hydrogenolysis Nitriles Drug Discovery Side chain Organic chemistry Physical and Theoretical Chemistry Isoxazole Furans Cycloaddition Reaction isoxazole Organic Chemistry Cycloaddition side-chain modifications chemistry Chemistry (miscellaneous) Alkynes Yield (chemistry) Molecular Medicine Acid hydrolysis |
| Zdroj: | Molecules Volume 17 Issue 10 Pages 12151-12162 Molecules, Vol 17, Iss 10, Pp 12151-12162 (2012) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules171012151 |
| Popis: | A series of 3(2H)-furanones, based on side-chain modifications of a parent 3(2H)-furanone, was synthesized in good yield. The parent compound was prepared by hydrogenolysis, and subsequent acid hydrolysis, of isoxazole derivatives. The isoxazole was prepared by a [3+2] 1,3-dipolar cycloaddition reaction between 3-butyn-2-ol and nitrile oxide. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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