A comparative study on solubility improvement of tetracycline and dexamethasone by poly(propylene imine) and polyamidoamine dendrimers: An insight into cytotoxicity and cell proliferation
| Autor: | Hossein Roghani-Mamaqani, Mehdi Salami-Kalajahi, Amir Kahaie-Khosrowshahi, Faezeh Najafi |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Dendrimers
Materials science Nitrile 0206 medical engineering Biomedical Engineering 02 engineering and technology Polypropylenes Dexamethasone Cell Line Biomaterials chemistry.chemical_compound Dendrimer Polyamines Humans MTT assay Solubility Cytotoxicity Glucocorticoids Cell Proliferation Drug Carriers Cell growth Metals and Alloys 021001 nanoscience & nanotechnology 020601 biomedical engineering Combinatorial chemistry chemistry Tetracyclines Drug delivery Ceramics and Composites Michael reaction 0210 nano-technology |
| Zdroj: | Journal of biomedical materials research. Part AREFERENCES. 108(3) |
| ISSN: | 1552-4965 |
| Popis: | Many of new chemical discovered in pharmaceutical industry are hydrophobic compounds. Various techniques have been used to overcome solubility problems of hydrophobic drugs in aqueous media. In the meantime, dendrimers have been considered for sustainability, nanoscale size, high carry capacity, tunable terminal functional groups in terms of drug delivery and solubility. In this work, we have synthesized poly(propylene imine) (PPI) dendrimer up to fifth generation using reduction of nitrile groups after Michael addition and also, polyamidoamine (PAMAM) dendrimer up to fourth generation using Michael addition and amidation reactions. fourth and fifth generations of PPI dendrimer and fourth and third generations of PAMAM dendrimer in different concentrations were used to evaluate the solubility of two hydrophobic drugs (tetracycline and dexamethasone). Furthermore, cytotoxicity of dendrimers and dendrimers/drugs hybrids was studied. The results showed that with increasing concentrations and also the generation of dendrimers, the solubility of these two hydrophobic drugs was increased. Cytotoxicity study through MTT assay against Osteoblast-like cell line (MG-63 cells) showed that dendrimers were relatively cytotoxic where adding dexamethasone caused higher cytotoxicity. However, tetracycline showed no significant effect on cytotoxicity whereas prevented cell proliferation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text