Paraffin-Coated Hydrophobic Hemostatic Zeolite Gauze for Rapid Coagulation with Minimal Adhesion

Autor:	Liping Xiao, Chaojie Shi, Jianzhou Wu, Wenzhao Zhang, Dan Li, Yu Lisha, Hao Chen, Jie Fan
Rok vydání:	2021
Předmět:	Materials science biology Adhesion engineering.material Fibrin Chemical engineering Clotting time Coating In vivo Hemostasis biology.protein engineering Coagulation (water treatment) General Materials Science Zeolite
Zdroj:	ACS Applied Materials & Interfaces. 13:52174-52180
ISSN:	1944-8252 1944-8244
DOI:	10.1021/acsami.1c10891
Popis:	To solve the problem of strong adhesion and excessive blood loss caused by the use of hydrophilic zeolite gauze (Z-Gauze) in uncontrollable bleeding, we have modified the surface of commercial Z-Gauze with a paraffin coating and prepared a hydrophobic dressing PZ-Gauze. After paraffin coating, the adhesion of Z-Gauze was reduced without an obvious decrease in coagulation activity. The clotting time of the hydrophobic PZ-Gauze was reduced from 378.3 to 154.6 s compared with that of cotton gauze, and the peeling force was decreased from 348.8 to 84.7 mN compared with that of Z-Gauze. Besides, PZ-Gauze can efficiently cut down the blood loss during treatment. On the basis of in vitro and in vivo experiments, it is confirmed that surface hydrophobic modification does not change the procoagulant performance because of the maintained cation exchange capacity of zeolites, and the reduced blood loss as well as enhanced difficulty for fibrin adhesion is attributed to its hydrophobicity. This is different from the traditional gauze procoagulant theories, where gauze hydrophilicity and procoagulant performance are always positively correlated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f57cf5a1e036eee1a1ffa929c6bd2642 https://doi.org/10.1021/acsami.1c10891 Zobrazit plný text záznamu