Immunolocation of Heme Oxygenases in the Walls of Cerebral Arteries of Various Diameters in Rats
| Autor: | A. E. Kotsyuba, V. M. Chertok |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
Oxygenase Pathology medicine.medical_specialty Endothelium Arsenites Cerebral arteries 030204 cardiovascular system & hematology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine.artery medicine Animals Myocyte Rats Wistar Heme Muscle Cells General Medicine Cerebral Arteries Sodium Compounds Rats Heme oxygenase medicine.anatomical_structure nervous system chemistry Heme Oxygenase (Decyclizing) Middle cerebral artery cardiovascular system Immunohistochemistry Heme Oxygenase-1 030217 neurology & neurosurgery circulatory and respiratory physiology |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 163:276-279 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-017-3783-1 |
| Popis: | The distribution of two enzymes involved in the formation of carbon monoxide, heme oxygenases 1 and 2, in the pial branches of orders I-V of the middle cerebral artery basin and in intracerebral vessels was studied in adult Wistar rats. Immunohistochemical studies detected hemeoxygenase-2 in the endothelium of the small pial and intracerebral arterioles and in myocytes of pial branches I-III. Heme oxygenase 1, an inducible form of the enzyme, is normally not expressed in the cerebral vessels, but the enzyme is expressed in response to sodium metaarsenite. In this case, heme oxygenase markers are detected in myocytes of pial arteries I-II and in the endothelium of small pial and intracerebral vessels. Sodium meta-arsenite is inessential for immunolocation and quantitative distribution of heme oxygenase 2 in the vessels. |
| Databáze: | OpenAIRE |
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