Production of insulin-like growth factor-binding proteins during the development of hepatic fibrosis due to chronic hepatitis C
| Autor: | Moisés Martínez-Castillo, José Luis Pérez-Hernández, D. Rosique-Oramas, F. Aragón, Gabriela Gutierrez-Reyes, Aldo Torre, J. Limón-Castillo, A. Raya, F. Higuera-de la Tijera, Zaira Medina-Avila, A. Santoyo, David Kershenobich, Eduardo E. Montalvo-Javé, A. Hernández-Barragán |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Gastroenterology Insulin-like growth factor-binding protein 03 medical and health sciences 0302 clinical medicine Chronic hepatitis Fibrosis Internal medicine medicine IGFBP 030212 general & internal medicine lcsh:RC799-869 Fibrosis hepática Receiver operating characteristic biology FibroTest business.industry Growth factor General Medicine medicine.disease Biomarcadores 030228 respiratory system Mann–Whitney U test biology.protein lcsh:Diseases of the digestive system. Gastroenterology Hepatic fibrosis business hormones hormone substitutes and hormone antagonists Hepatitis C crónica |
| Zdroj: | Revista de Gastroenterología de México (English Edition), Vol 85, Iss 4, Pp 390-398 (2020) |
| Popis: | Introduction and Aims: Insulin-like growth factor 1 is modulated by the insulin-like growth factor-binding proteins (IGFBPs) that are synthesized in the liver. The aim of the present study was to evaluate the concentrations of IGFBPs 1–7 in patients with chronic hepatitis C and study their association with fibrosis stage. Patients and methods: A prospective, cross-sectional study was conducted that included patients with chronic hepatitis C. The stages of fibrosis were determined through FibroTest and FibroScan and the patients were compared with a control group. Serum levels of IGFBPs 1–7 were quantified through multiple suspension arrays. The Kruskal-Wallis test, Mann-Whitney U test, Spearman’s correlation, and ROC curves were used for the statistical analysis. Results: Upon comparing the patients and controls, the highest concentrations were found in IGFBPs 1, 2, 4, and 7 (p = 0.02, 0.002, 0.008, and |
| Databáze: | OpenAIRE |
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