An integrated young interferometer based on UV-imprinted polymer waveguides for label-free biosensing applications
| Autor: | Jussi Hiltunen, Leena Hakalahti, Meng Wang, Risto Myllylä, Christina Liedert |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
chemistry.chemical_classification
Detection limit Materials science Fabrication planar waveguide biosensors business.industry Polymer Cladding (fiber optics) young interferometer Atomic and Molecular Physics and Optics Buffer (optical fiber) polymer waveguide Interferometry Optics chemistry UV-imprinting lithography Optoelectronics business Biosensor Refractive index |
| Zdroj: | Wang, M, Hiltunen, J, Liedert, C, Hakalahti, L & Myllylä, R 2012, ' An integrated young interferometer based on UV-imprinted polymer waveguides for label-free biosensing applications ', Journal of the European Optical Society: Rapid Publications, vol. 7 . https://doi.org/10.2971/jeos.2012.12019 |
| DOI: | 10.2971/jeos.2012.12019 |
| Popis: | We demonstrate a polymer rib waveguide Young interferometer sensor fabricated by UV-imprinting. An inverted rib waveguide structure was utilized in order to simplify the fabrication process. In this configuration grooves are formed on the under cladding layer by UV-imprinting and core material is spin coated on top to fill the grooves. Glucose water solution was used to characterize the sensor response against ambient refractive index changes. The sensing responses correspond linearly with the refractive index change of glucose solutions with a detection limit of about 10-5. To verify the capability of the polymer sensor for biosensing, an immunoassay was performed with c-reactive protein (CRP) and human CRP specific antibody adsorbed on the waveguide surface as a receptor. The CRP solution in PBS (phosphate buffered saline) buffer with a concentration of 2 µg/ml (16 nM) resulted in an obvious response which was over a couple hundred times of the noise level. Based on these values, a detection limit of about 2.4 pg/mm2 was found for the surface sensing of molecular adsorption. With the proposed waveguide configuration, the fabrication of polymer sensors can be ultimately transferred to roll-to-roll mass production to produce low-cost disposable sensors. |
| Databáze: | OpenAIRE |
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