Immunochemical Relationships of Certain Capsular Polysaccharides of Klebsiella, Pneumococci and Rhizobia

Autor:	M, Heidelberger, W F, Dudman, W, Nimmich
Rok vydání:	1970
Předmět:	Binding Sites Nitrogen Immune Sera Immunochemistry Polysaccharides Bacterial Immunology Galactose Cross Reactions Rhamnose Antigen-Antibody Reactions Epitopes Streptococcus pneumoniae Klebsiella Animals Immunology and Allergy Horses Pyruvates Rhizobium
Zdroj:	The Journal of Immunology. 104:1321-1328
ISSN:	1550-6606 0022-1767
DOI:	10.4049/jimmunol.104.6.1321
Popis:	Pyruvic acid is an immunologic determinant in the capsular polysaccharides of Klebsiella K32, pneumococcal types IV and XXVII, and eight strains of Rhizobia. All of these react heavily in anti-Pn XXVII. A cross-reaction between Pn IV and Pn XXVII is described and shown not to be due to pyruvic acid. Klebsiella K9 is characterized by non-reducing end-groups of D-glucuronic acid (or of 4-O-methyl-d-glucuronic acid) but differs in other respects from K2. Cross-reactions of K47 show it to be the only one of those tested with non-reducing end-groups of l-rhamnose. K52 reacts heavily in anti-Pn XXVIII. When depyruvylated, the rhizobial polysaccharides show much greater reactivity, and, occasionally, different reactivities in anti-Pn sera other than XXVII, in which depyruvylation virtually abolishes precipitation. The rhizobial polysaccharides may contain their pyruvic acid linked as a ketal to d-galactose; the linkage in S IV is more labile.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f57ab9fe10f1b11f6786fd5265927416 https://doi.org/10.4049/jimmunol.104.6.1321 Zobrazit plný text záznamu