Human Pythiosis Associated with Thalassemia Hemoglobinopathy Syndrome
| Autor: | Vichai Atichartakarn, Timothy W. Flegel, Roongnapa Prachaktam, Boonmee Sathapatayavongs, Suwattana Nontasut, Charindr Eurvilaichit, Prasert Trairatvorakul, Paisan Leelachaikul, Sopon Jirasiritham, Suthus Sriphojanart |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
medicine.medical_specialty
Blood transfusion medicine.medical_treatment Thalassemia Pythium Pythium insidiosum Gastroenterology Pythiosis Amphotericin B Internal medicine medicine Humans Immunology and Allergy Arteritis Gangrene biology business.industry Syndrome Middle Aged medicine.disease biology.organism_classification Surgery Chytridiomycota Infectious Diseases Hemoglobinopathy Mycoses Female business medicine.drug |
| Zdroj: | Journal of Infectious Diseases. 159:274-280 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/159.2.274 |
| Popis: | Pythium infection (pythiosis) in humans has not previously been described, even in areas endemic for animal pythiosis. We report five patients with a unique presentation of fungal arteritis. The medium- to large-sized arteries were involved, and in some cases this involvement led to gangrene of the limbs, aneurysm formation, and ultimately fatal arterial leakage. All five patients were farmers. All patients, with the possible exception of one who had hemoglobin typing performed after receiving a blood transfusion, had thalassemia hemoglobinopathy syndrome. Fungal isolation was difficult. Amphotericin B treatment seemed to be ineffective. Radical surgical removal of infected tissues and oral administration of a saturated solution of potassium iodide are proposed therapy. In the tropics, where Pythium is ubiquitous, one should actively look for this fungal infection in patients with unexplained arterial occlusion, especially in the case of patients with thalassemia hemoglobinopathy syndrome. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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