Asynchronous regional brain volume losses in presymptomatic to moderate AD
| ISSN: | 1875-8908 1387-2877 |
|---|---|
| DOI: | 10.3233/jad-2005-8106 |
| Přístupová URL adresa: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f57917d9faf7dfabbc213c1560becaed https://doi.org/10.3233/jad-2005-8106 |
| Přírůstkové číslo: | edsair.doi.dedup.....f57917d9faf7dfabbc213c1560becaed |
| Autor: | B. Care, Diane B. Howieson, M. M. Moore, Joseph F. Quinn, Alison Dame, Jeffrey Kaye, Gary Sexton, G. Nesbit, Richard Camicioli, E. Corbridge |
| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Clinical Dementia Rating Basal Ganglia Cerebral Ventricles Temporal lobe Atrophy Alzheimer Disease Internal medicine mental disorders Image Processing Computer-Assisted medicine Humans Dementia Longitudinal Studies Dominance Cerebral Prospective cohort study Aged Cerebrospinal Fluid Aged 80 and over Cerebral Cortex medicine.diagnostic_test General Neuroscience Brain Magnetic resonance imaging General Medicine medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health Clinical Psychology Brain size Disease Progression Cardiology Female Geriatrics and Gerontology Alzheimer's disease Mental Status Schedule Psychology Neuroscience |
| Zdroj: | Journal of Alzheimer's Disease. 8:51-56 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-2005-8106 |
| Popis: | To determine if rates and locations of brain volume loss associated with AD are phase-specific, occurring prior to clinical onset and at later stages, we performed longitudinal volumetric MRI analysis on 155 subjects enrolled in a prospective study of aging and dementia. Subjects were divided by Clinical Dementia Rating (CDR) scale into stages of Normal (CDR 0 --> 0), Very Mild (CDR 0 --> 0.5 and 0.5 --> 0.5), Mild (CDR 0.5 --> 1.0 and 1.0 --> 1.0) and Moderate (CDR 1.0 --> 2.0 and 2.0 --> 2.0) dementia. Rates of volume change in CSF spaces, lobar and medial temporal lobe regions were analyzed for group differences across stages. Annual rates of ventricular volume change differed between non-demented and very mild group (p |
| Databáze: | OpenAIRE |
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