Functional Plasticity Induced by Mirror Training: The Mirror as the Element Connecting Both Hands to One Hemisphere

Autor: Volkmar Glauche, Cornelius Weiller, Farsin Hamzei, C. H. Läppchen, Michel Rijntjes, Irina Mader
Jazyk: angličtina
Předmět:
Adult
Male
medicine.medical_specialty
Imagery
Psychotherapy
Time Factors
Movement
media_common.quotation_subject
Models
Neurological
Electromyography
Brain mapping
Functional Laterality
050105 experimental psychology
Premotor cortex
Young Adult
03 medical and health sciences
0302 clinical medicine
Physical medicine and rehabilitation
Neuroplasticity
Motor system
Image Processing
Computer-Assisted
medicine
Humans
0501 psychology and cognitive sciences
Mirror neuron
Paresis
media_common
Brain Mapping
Communication
Neuronal Plasticity
medicine.diagnostic_test
business.industry
05 social sciences
Motor Cortex
General Medicine
Hand
Magnetic Resonance Imaging
Oxygen
medicine.anatomical_structure
Nonlinear Dynamics
Female
medicine.symptom
business
Psychology
Imitation
Psychomotor Performance
030217 neurology & neurosurgery
Popis: Background. Mirror therapy (MT) is a promising therapeutic approach in stroke patients with severe hand paresis. Objective. The ipsilateral (contralesional) primary sensorimotor cortex (SMC) and the mirror neuron system have been suggested to play decisive roles in the MT network. The present study investigated its underlying neural plasticity. Methods. Two groups of healthy participants (n = 13 in each group) performed standardized fine motor tasks moving pegs and marbles (20 min/d for 4 days) with their right hand with either a mirror (mirror training group, MG) or a nonreflective board (control training group, CG) positioned orthogonally in front of them. The number of items moved by each hand was tested after each training session. Functional MRI (fMRI) was acquired before and after the training procedure to investigate the mirror training (MTr)-specific network by the analysis of the factors Time and Group. Results. The hand performance test of the trained right hand did not differ between the 2 groups. The untrained left hand improved significantly more in the MG compared with the CG. fMRI analysis of action observation and imitation of grasping tasks demonstrated MTr-specific activation changes within the right dorsal and left ventral premotor cortex as well as in the left SMC (SMCleft). Analysis of functional and effective connectivity showed a MTr-specific increase of functional coupling between each premotor region and the left supplementary motor area, which in turn showed an increased functional interaction with the ipsilateral SMCleft. Conclusions. MTr remodels the motor system by functionally connecting hand movement to the ipsilateral SMC. On a system level, it leads to interference of the neural circuit related to motor programming and observation of the trained hand with the illusionary movement of the untrained hand.
Databáze: OpenAIRE
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