Mean platelet volume: interactions with platelet aggregation activity and glycoprotein IIb-IIIa and Ib expression levels
| Autor: | A. V. Mazurov, I. T. Zyuryaev, S. G. Khaspekova, Ya. A. Naimushin, M. Ya. Ruda, N. O. Zaytseva, V. V. Yakushkin, O. V. Sirotkina |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Blood Platelets
Male medicine.medical_specialty Ticlopidine Platelet Aggregation Fibrinogen receptor Gene Expression Platelet Glycoprotein GPIIb-IIIa Complex General Biochemistry Genetics and Molecular Biology Thromboxane A2 chemistry.chemical_compound Von Willebrand factor Risk Factors Internal medicine medicine Humans Platelet Acute Coronary Syndrome Mean platelet volume Polymorphism Genetic Aspirin biology business.industry Thrombosis General Medicine Middle Aged Prognosis Clopidogrel Adenosine Diphosphate Endocrinology Platelet Glycoprotein GPIb-IX Complex Glycoprotein Ib chemistry Case-Control Studies Immunology biology.protein Female Glycoprotein IIb/IIIa business Mean Platelet Volume Platelet Aggregation Inhibitors medicine.drug |
| Zdroj: | Biomeditsinskaya Khimiya. 60:94-108 |
| ISSN: | 2310-6905 2310-6972 |
| DOI: | 10.18097/pbmc20146001094 |
| Popis: | Increased mean platelet volume (MPV) is an independent risk factor of thrombotic events in patients with cardiovascular diseases. Interactions of MPV with platelet aggregation activity and contents of glycoprotein (GP) IIb-IIIa (aIIb/b3 integrin, fibrinogen receptor) and GP Ib (von Willebrand factor receptor) were investigated in this study. Investigation was performed in a group of healthy volunteers (n = 38) and in a group of patients with acute coronary syndrome (ACS). In patients blood was collected at days 1, 3-5 and 8-12 after ACS development. As an antiaggregant therapy all patients received acetylsalicylic acid (ASA, inhibitor of thromboxane A2 synthesis) and most of them – clopidogrel (ADP receptor antagonist) with the exception of part of the patients (n=44) at day 1 who had not taken clopidogrel before first blood collection. In volunteers platelet aggregation was stimulated by 1.25, 2.5, 5 and 20 M ADP, and in patients – by 5 and 20 M ADP. GP IIb-IIIa and GP Ib content on platelet surface was measured using 125I-labelled monoclonal antibodies. GP IIb-IIIa and GP Ib genetic polymorphisms were determined in ACS patients. In healthy donors significant correlations between MPV and aggregation levels were revealed at 1.25 and 2.5 M ADP (coefficients of correlation (r) - 0.396 and 0.373, p0.05). Correlations between MPV and aggregation levels were observed at day 1 of ACS in a subgroup of patients who received ASA but had not started clopidogrel treatment (r - 0.526, p |
| Databáze: | OpenAIRE |
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