Effect of Acute and Chronic Buspirone Administration on Communicativeness of Mice with Experience of Defeats in Social Conflicts
| Autor: | Damira F. Avgustinovich, L. A. Koryakina, Galina B. Vishnivetskaya |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
Agonist Single administration medicine.medical_specialty Time Factors medicine.drug_class Statistics Nonparametric General Biochemistry Genetics and Molecular Biology Communicative behavior Buspirone Conflict Psychological Mice Internal medicine medicine Animals Social Behavior business.industry General Medicine Animal Communication Mice Inbred C57BL Endocrinology Receptor Serotonin 5-HT1A Conflict (Psychology) business medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 149:57-61 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-010-0875-6 |
| Popis: | We studied the effect of 5-HT(1A)receptor agonist buspirone on behavior of male C57Bl/6J mice in the "partition" test, which reflects communicativeness of animals. Single administration of buspirone (1 mg/kg) to intact mice and animals experienced defeats in 20 intermale confrontations impaired their communicativeness, especially in intact animals. On the contrary, administration of buspirone (1 mg/kg) to losers starting from day 5 of intermale confrontations for 2 weeks produced a positive effect and prevented impairment of communicativeness by day 20 of confrontations. The role of brain 5-HT(1A)receptors in these processes is discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink