Vascular endothelial growth factor and its receptors in the placenta of pregnant women with obesity
| Autor: | M. A. Bayramova, Pavlov Ka, I. O. Makarov, Shchegolev Ai, E. I. Borovkova, Dubova Ea |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Vascular Endothelial Growth Factor A medicine.medical_specialty Endothelium Angiogenesis Placenta Gene Expression Biology General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Syncytiotrophoblast Pregnancy Internal medicine medicine Humans Obesity reproductive and urinary physiology Cytotrophoblast integumentary system General Medicine Trophoblasts Vascular endothelial growth factor Vascular endothelial growth factor B medicine.anatomical_structure Endocrinology Receptors Vascular Endothelial Growth Factor chemistry Vascular endothelial growth factor C Case-Control Studies embryonic structures cardiovascular system Female Endothelium Vascular Chorionic Villi |
| Zdroj: | Bulletin of experimental biology and medicine. 151(2) |
| ISSN: | 1573-8221 |
| Popis: | Comparative morphological study of placentas from women with obesity and normal body weight was performed. Expression of vascular endothelial growth factor (VEGF) and its receptors (VEGFR-1, VEGFR-2, VEGFR-3) was detected by immunohistochemical methods. Nonbranching angiogenesis predominated in the placentas from obese women. Immunohistochemical analysis showed reduced intensity of the reaction to VEGF in the syncytiotrophoblast and vascular endothelium of stem villi and enhanced VEGF expression in non-villous cytotrophoblast and endothelial cells of capillaries of mature intermediate and terminal villi; reduced expression of VEGFR-1 and increased levels of VEGFR-2 and VEGFR-3 in the studied structures were also noted. |
| Databáze: | OpenAIRE |
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