Limitations of Immunohistochemistry in Diagnosis of a Primary Mucinous Carcinoma of the Skin and Its Metastasis
| Autor: | Mann C, Schad A, Mann W, Weidenthaler-Barth B |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty Context (language use) Immunostaining Metastasis Lesion 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Mammaglobin Breast cancer Diagnosis Carcinoma Medicine Mucinous carcinoma biology business.industry Asploro Journal of Biomedical and Clinical Case Reports General Medicine medicine.disease Immunohistochemistry Primary tumor 030220 oncology & carcinogenesis biology.protein medicine.symptom business |
| Zdroj: | Asploro Journal of Biomedical and Clinical Case Reports. 4:11-15 |
| ISSN: | 2582-0370 |
| DOI: | 10.36502/2021/asjbccr.6222 |
| Popis: | We describe the case of a 67-year-old female patient who presented with an unclear swelling on the right supraclavicular neck, two years after resection of a mucinous carcinoma on the right mastoid. Two pathological reports from separate universities diagnosed the primary mastoid skin lesion as a metastatic adenocarcinoma. Strikingly, GATA binding protein 3 (GATA3) and mammaglobin, both immunomarkers found in breast cancer, were positive. An urgent search for the primary tumor most likely in the breast was commenced. However, as no other primary tumor could be detected at that time, a Primary Mucinous Carcinoma of the Skin (PMCS) was also debated. Two years later neck node enlargement was suspicious for lymph node metastasis during ultrasound examination and conservative neck dissection was performed. Immunohistochemistry revealed again GATA 3, Mammaglobin, estrogen, and progesterone receptor positive tissue. Using a variety of other markers, we were unable to detect neither significant morphological nor immunohistochemical characteristics that distinguished the lesion from a mucinous carcinoma of mammary origin. Following a detailed review of the clinical context, we concluded the lesion to be consistent with a late metastasis of a PMCS. This report demonstrates the limitations of currently used histopathological and immunohistochemical differentiation in metastatic mucinous carcinoma. |
| Databáze: | OpenAIRE |
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