| Autor: |
Elder, MJ, Webster, SJ, Chee, W, Williams, DL, Gaston, JSH, Goodall, JC |
| Přispěvatelé: |
Webster, Steven [0000-0002-0864-1182], Gaston, Hill [0000-0002-5789-5111], Goodall, Jane [0000-0002-3761-161X], Apollo - University of Cambridge Repository |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Frontiers in Immunology, Vol 8 (2017) |
| ISSN: |
1664-3224 |
| DOI: |
10.3389/fimmu.2017.00791 |
| Popis: |
Dectin-1/CLEC7A is a pattern recognition receptor that recognizes β-1,3 glucans, and its stimulation initiates signaling events characterized by the production of inflammatory cytokines from human dendritic cells (DCs) required for antifungal immunity. β-glucans differ greatly in size, structure, and ability to activate effector immune responses from DC; as such, small particulate β-glucans are thought to be poor activators of innate immunity. We show that β-glucan particle size is a critical factor contributing to the secretion of cytokines from human DC; large β-glucan-stimulated DC generate significantly more IL-1β, IL-6, and IL-23 compared to those stimulated with the smaller β-glucans. In marked contrast, the secretion of TSLP and CCL22 were found to be insensitive to β-glucan particle size. Furthermore, we show that the capacity to induce phagocytosis, and the relative IL-1β production determined by β-glucan size, regulates the composition of the cytokine milieu generated from DC. This suggests that β-glucan particle size is critically important in orchestrating the nature of the immune response to fungi. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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