Autoantibodies to Sympathetic Ganglia, GAD, or Tyrosine Phosphatase in Long-Term IDDM With and Without ECG-Based Cardiac Autonomic Neuropathy

Autor: Eberhard Standl, Manfred Haslbeck, Daniela Muhr, Anette-Gabriele Ziegler, Oliver Schnell, U. Mollenhauer
Rok vydání: 1997
Předmět:
Adult
Male
medicine.medical_specialty
Sympathetic nervous system
endocrine system diseases
Heart disease
Valsalva Maneuver
Endocrinology
Diabetes and Metabolism
Autoantigens
Electrocardiography
Diabetic Neuropathies
Heart Rate
Reference Values
Diabetes mellitus
Internal medicine
Immunopathology
Internal Medicine
Humans
Medicine
Receptor-Like Protein Tyrosine Phosphatases
Class 8
Fluorescent Antibody Technique
Indirect
Autoantibodies
Protein Tyrosine Phosphatase
Non-Receptor Type 1
Advanced and Specialized Nursing
Autoimmune disease
geography
Ganglia
Sympathetic
geography.geographical_feature_category
biology
Glutamate Decarboxylase
business.industry
Autoantibody
Membrane Proteins
food and beverages
Heart
medicine.disease
Islet
Diabetes Mellitus
Type 1
Endocrinology
medicine.anatomical_structure
biology.protein
Female
Protein Tyrosine Phosphatases
Antibody
business
Zdroj: Diabetes Care. 20:1009-1012
ISSN: 1935-5548
0149-5992
DOI: 10.2337/diacare.20.6.1009
Popis: OBJECTIVE To evaluate the association of autoantibodies to complement-fixing sympathetic ganglia (CF-SG), and tyrosine phosphatase (IA-2) with electrocardiogram (ECG)-based cardiac autonomic neuropathy (CAN) in long-term IDDM. RESEARCH DESIGN AND METHODS We examined the prevalence of autoantibodies to CF-SG (by complement-fixing indirect immunoflourescence), GAD, and IA-2 (by radioligand assay) and islet cells (by indirect immunofluorescence) in 96 long-term IDDM patients (41 with ECG-based CAN, ≥ 2 of 5 cardiac reflex tests abnormal; 55 without ECG-based CAN). As a control group, 89 healthy nondiabetic subjects were investigated. RESULTS CF-SG autoantibodies were observed more frequently in long-term IDDM patients than in the control group (25 vs. 4%, P = 0.0001). Of the IDDM patients, 14 (34%) with CAN and 10 (18%) without CAN presented with CF-SG autoantibodies (P = 0.06). GAD or IA-2 autoantibodies were detected in 14 (34%) and 17 (41%) IDDM patients with CAN, compared with 24 (44%) and 29 (53%) IDDM patients without CAN (P = 0.2, P = 0.2). Islet cell antibodies were observed in 6 (15%) IDDM patients with and in 9 (16%) IDDM patients without CAN (P = 0.5). CONCLUSIONS In long-term IDDM, the role of CF-SG autoantibodies, which tend to be more frequent in patients with ECG-based CAN, requires further investigations. The persistence of GAD and IA-2 autoantibodies is not related to ECG-based CAN.
Databáze: OpenAIRE
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