Severity of Deliberate Acute Baclofen Poisoning: A Nonconcurrent Cohort Study

Autor: Mireille Bartoli, Maignan Maxime, Guillaume Debaty, Vincent Danel, Damien Viglino, Philippe Pommier, Françoise Carpentier
Přispěvatelé: Université Grenoble Alpes - UFR Médecine (UGA UFRM), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Physiologie cardio-Respiratoire Expérimentale Théorique et Appliquée (TIMC-IMAG-PRETA), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), Centre Hospitalier Universitaire [Grenoble] (CHU), Service d'accueil des urgences médicales, CHU Grenoble, Samu 38
Rok vydání: 2013
Předmět:
Adult
Male
Baclofen
Endpoint Determination
medicine.medical_treatment
Aspiration Pneumonitis
Toxicology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Seizures
medicine
Humans
030212 general & internal medicine
ComputingMilieux_MISCELLANEOUS
Retrospective Studies
Pharmacology
Mechanical ventilation
Dose-Response Relationship
Drug
business.industry
organic chemicals
musculoskeletal
neural
and ocular physiology
Alcohol dependence
Retrospective cohort study
General Medicine
Middle Aged
Acute toxicity
3. Good health
body regions
Alcoholism
Intensive Care Units
Logistic Models
Treatment Outcome
nervous system
chemistry
Anesthesia
Relative risk
Female
Drug Overdose
business
030217 neurology & neurosurgery
Cohort study
Zdroj: Basic and Clinical Pharmacology and Toxicology
Basic and Clinical Pharmacology and Toxicology, Wiley, 2014, 114 (4), pp.360-364. ⟨10.1111/bcpt.12161⟩
ISSN: 1742-7835
1742-7843
Popis: Interest in high-dose baclofen treatment for alcohol dependence has increased over the past few years. In the meantime, the rate of acute baclofen poisoning has increased and life-threatening cases have been reported. Thus, severity of acute poisoning could lessen the benefit of baclofen treatment. Our aim was to evaluate the severity of acute baclofen poisoning independently of confounders and to assess whether severity is correlated with the reported ingested dose. We prospectively included consecutive patients with acute and deliberate baclofen overdose and compared them with gender and age-matched patients from a retrospective cohort of common acute medicine self-poisoning. The primary end-point was the adjusted risk ratio of mechanical ventilation. We also analysed the lengths of mechanical ventilation and risks of aspiration pneumonitis and convulsions. We finally examined the correlation between the supposed reported ingested dose and the severity of poisoning. Fourteen baclofen-poisoned patients were included and matched to 56 poisoned patients. Median age was 45 y/o (40-58), and men comprised 43% of patients. In logistic regression, the adjusted risk ratio of mechanical ventilation was 7.9 (1.4-43.5; p=0.02) for baclofen-treated patients. Aspiration pneumonitis was more frequent in baclofen-treated patients (29% versus 2%; p=0.005), and the length of mechanical ventilation was significantly correlated with the reported ingested dose of baclofen (Spearman coefficients: 0.48; p
Databáze: OpenAIRE
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