Dramatic but suspensive effect of interleukin-1 inhibitors for persistent urticarial vasculitis: a French multicentre retrospective study
| Autor: | Julien Wipff, Thomas Bettuzzi, Marie Jachiet, Selim Aractingi, Benjamin Terrier, Meryem-Maud Farhat, Marc Fabre, Alban Deroux, Nicolas Dupin, Laurence Bouillet, Nora Kramkimel |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Vasculitis 0301 basic medicine Systemic disease medicine.medical_specialty Urticaria Immunology Dapsone General Biochemistry Genetics and Molecular Biology Young Adult 03 medical and health sciences 0302 clinical medicine Rheumatology Refractory Humans Immunology and Allergy Medicine Urticarial vasculitis Retrospective Studies 030203 arthritis & rheumatology Biological Products business.industry Interleukin Retrospective cohort study Middle Aged medicine.disease Dermatology Treatment Outcome 030104 developmental biology Female Rituximab France business Interleukin-1 medicine.drug Systemic vasculitis |
| Zdroj: | Annals of the Rheumatic Diseases. 78:1446-1448 |
| ISSN: | 1468-2060 0003-4967 |
| DOI: | 10.1136/annrheumdis-2019-215605 |
| Popis: | Urticarial vasculitis (UV) is rare systemic disease characterised by a dermal capillary inflammation responsible of long-lasting urticarial lesions, and sometimes some systemic manifestations.1 2 UV can be separated into two different entities: hypocomplementemic UV (HUV) and normocomplementemic UV (NUV). Treatment of UV depends on the severity of the disease and the occurrence of relapses. In patients refractory to colchicine or dapsone, glucocorticoids (GCs), conventional immunosuppressive agents or rituximab (RTX) can be used,1 2 leading to significant morbidity. Interleukin-1β (IL-1β) inhibitors are biologics mainly used in autoinflammatory diseases.3 We report here a French retrospective multicentr study of patients treated with IL-1β inhibitors for persistent disease despite GCs and/or immunosuppressive agents. This French retrospective multicentre study was conducted in four departments of Dermatology and Internal Medicine. We included patients with persistent UV to at … |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|