Vitamin D status and risk of infections after liver transplantation in the Swiss Transplant Cohort Study

Autor: Schreiber, Peter W, Bischoff-Ferrari, Heike A, Boggian, Katia, van Delden, Christian, Enriquez, Natalia, Fehr, Thomas, Garzoni, Christian, Hirsch, Hans H, Hirzel, Cédric, Manuel, Oriol, Meylan, Pascal, Saleh, Lanja, Weisser, Maja, Mueller, Nicolas J, Swiss Transplant Cohort Study
Přispěvatelé: University of Zurich, Mueller, Nicolas J, Chalandon, Yves, Gasche-Soccal, Paola Marina Alessandra, Lovis, Christian, Majno, Pietro, Martin, Pierre-Yves, Posfay Barbe, Clara, Toso, Christian, Villard, Jean
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
11221 Clinic for Geriatric Medicine
2747 Transplantation
medicine.medical_treatment
Liver Transplantation/adverse effects
030230 surgery
Liver transplantation
Rate ratio
Gastroenterology
10234 Clinic for Infectious Diseases
Postoperative Complications
0302 clinical medicine
Risk Factors
Medicine
Poisson Distribution
Prospective Studies
Vitamin D
610 Medicine & health
Prospective cohort study
10038 Institute of Clinical Chemistry
ddc:617
Bacterial Infections
Middle Aged
Vitamin D/blood
Post-transplant care
Liver Failure/blood/surgery
10209 Clinic for Cardiology
Regression Analysis
Female
030211 gastroenterology & hepatology
Vitamin D Deficiency/complications
10178 Clinic for Pneumology
Switzerland
Cohort study
Adult
medicine.medical_specialty
Infections
vitamin D deficiency
03 medical and health sciences
Internal medicine
Vitamin D and neurology
Humans
Risk factor
Aged
Transplantation
business.industry
Vitamin D Deficiency
medicine.disease
Liver Transplantation
10036 Medical Clinic
Multivariate Analysis
10032 Clinic for Oncology and Hematology
business
Bacterial Infections/epidemiology
Liver Failure
Zdroj: Transplant International, Vol. 32, No 1 (2019) pp. 49-58
Schreiber, Peter W; Bischoff-Ferrari, Heike A; Boggian, Katia; van Delden, Christian; Enriquez, Natalia; Fehr, Thomas; Garzoni, Christian; Hirsch, Hans H; Hirzel, Cédric; Manuel, Oriol; Meylan, Pascal; Saleh, Lanja; Weisser, Maja; Mueller, Nicolas J (2019). Vitamin D status and risk of infections after liver transplantation in the Swiss Transplant Cohort Study. Transplant international, 32(1), pp. 49-58. Wiley-Blackwell 10.1111/tri.13328
ISSN: 0934-0874
DOI: 10.1111/tri.13328
Popis: MAIN PROBLEM Increasing evidence indicates a role of vitamin D in the immune system affecting response to infections. We aimed to characterize the role of vitamin D status, i.e. deficiency (25-OH vitamin D [25-OHD] < 50nmol/l) and no deficiency (25-OHD ≥ 50nmol/l) in incident infections after liver transplantation. METHODS In 135 liver transplant recipients blood samples drawn at time of liver transplantation and 6 months afterwards were used to determine 25-OHD levels. Incident infections episodes were prospectively collected within the STCS database. Poisson regression was applied to address associations between vitamin D status and incident infections. RESULTS Vitamin D deficiency was common at time of transplantation and 6 months afterwards without a significant change in median 25-OHD levels. In univariable analyses vitamin D deficiency was a risk factor for incident infections in the first 6 months post-transplant (IRR 1.52, 95% CI 1.08-2.15, P=0.018) and for bacterial infections occurring after 6 up to 30 months post-transplant (IRR 2.29, 95% CI 1.06-4.94, P=0.034). These associations were not detectable in multivariable analysis with adjustment for multiple confounders. CONCLUSIONS Efforts to optimize vitamin D supplementation in liver transplant recipients are needed. Our data question the role of vitamin D deficiency in incident infections. This article is protected by copyright. All rights reserved.
Databáze: OpenAIRE
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