Vitamin D status and risk of infections after liver transplantation in the Swiss Transplant Cohort Study
Autor: | Schreiber, Peter W, Bischoff-Ferrari, Heike A, Boggian, Katia, van Delden, Christian, Enriquez, Natalia, Fehr, Thomas, Garzoni, Christian, Hirsch, Hans H, Hirzel, Cédric, Manuel, Oriol, Meylan, Pascal, Saleh, Lanja, Weisser, Maja, Mueller, Nicolas J, Swiss Transplant Cohort Study |
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Přispěvatelé: | University of Zurich, Mueller, Nicolas J, Chalandon, Yves, Gasche-Soccal, Paola Marina Alessandra, Lovis, Christian, Majno, Pietro, Martin, Pierre-Yves, Posfay Barbe, Clara, Toso, Christian, Villard, Jean |
Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
Male
11221 Clinic for Geriatric Medicine 2747 Transplantation medicine.medical_treatment Liver Transplantation/adverse effects 030230 surgery Liver transplantation Rate ratio Gastroenterology 10234 Clinic for Infectious Diseases Postoperative Complications 0302 clinical medicine Risk Factors Medicine Poisson Distribution Prospective Studies Vitamin D 610 Medicine & health Prospective cohort study 10038 Institute of Clinical Chemistry ddc:617 Bacterial Infections Middle Aged Vitamin D/blood Post-transplant care Liver Failure/blood/surgery 10209 Clinic for Cardiology Regression Analysis Female 030211 gastroenterology & hepatology Vitamin D Deficiency/complications 10178 Clinic for Pneumology Switzerland Cohort study Adult medicine.medical_specialty Infections vitamin D deficiency 03 medical and health sciences Internal medicine Vitamin D and neurology Humans Risk factor Aged Transplantation business.industry Vitamin D Deficiency medicine.disease Liver Transplantation 10036 Medical Clinic Multivariate Analysis 10032 Clinic for Oncology and Hematology business Bacterial Infections/epidemiology Liver Failure |
Zdroj: | Transplant International, Vol. 32, No 1 (2019) pp. 49-58 Schreiber, Peter W; Bischoff-Ferrari, Heike A; Boggian, Katia; van Delden, Christian; Enriquez, Natalia; Fehr, Thomas; Garzoni, Christian; Hirsch, Hans H; Hirzel, Cédric; Manuel, Oriol; Meylan, Pascal; Saleh, Lanja; Weisser, Maja; Mueller, Nicolas J (2019). Vitamin D status and risk of infections after liver transplantation in the Swiss Transplant Cohort Study. Transplant international, 32(1), pp. 49-58. Wiley-Blackwell 10.1111/tri.13328 |
ISSN: | 0934-0874 |
DOI: | 10.1111/tri.13328 |
Popis: | MAIN PROBLEM Increasing evidence indicates a role of vitamin D in the immune system affecting response to infections. We aimed to characterize the role of vitamin D status, i.e. deficiency (25-OH vitamin D [25-OHD] < 50nmol/l) and no deficiency (25-OHD ≥ 50nmol/l) in incident infections after liver transplantation. METHODS In 135 liver transplant recipients blood samples drawn at time of liver transplantation and 6 months afterwards were used to determine 25-OHD levels. Incident infections episodes were prospectively collected within the STCS database. Poisson regression was applied to address associations between vitamin D status and incident infections. RESULTS Vitamin D deficiency was common at time of transplantation and 6 months afterwards without a significant change in median 25-OHD levels. In univariable analyses vitamin D deficiency was a risk factor for incident infections in the first 6 months post-transplant (IRR 1.52, 95% CI 1.08-2.15, P=0.018) and for bacterial infections occurring after 6 up to 30 months post-transplant (IRR 2.29, 95% CI 1.06-4.94, P=0.034). These associations were not detectable in multivariable analysis with adjustment for multiple confounders. CONCLUSIONS Efforts to optimize vitamin D supplementation in liver transplant recipients are needed. Our data question the role of vitamin D deficiency in incident infections. This article is protected by copyright. All rights reserved. |
Databáze: | OpenAIRE |
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