Effectiveness of an immunocastration vaccine formulation to reduce the gonadal function in female and male mice by Th1/Th2 immune response
| Autor: | Daniela Siel, Francisco R. Carvallo, Rodolfo Paredes, Lisette Lapierre, Sonia Vidal, Oliver Pérez, Rafael Sevilla, Mario Maino, Leonardo Sáenz |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty medicine.medical_treatment Gonadotropin-releasing hormone Biology Antibodies Gonadotropin-Releasing Hormone Andrology Mice 03 medical and health sciences chemistry.chemical_compound Th2 Cells Immune system Adjuvants Immunologic Food Animals Internal medicine medicine Animals Castration Gonads Small Animals Chitosan Vaccines Equine Th1 Cells Recombinant Proteins Vaccination 030104 developmental biology Cytokine Endocrinology chemistry biology.protein Cytokines Female Immunization Animal Science and Zoology Antibody Adjuvant Hormone |
| Zdroj: | Theriogenology. 86:1589-1598 |
| ISSN: | 0093-691X |
| Popis: | Immunocastration has emerged as an alternative to surgical castration in different animal species. This study examined the effectiveness of a new vaccine formulation for immunocastration using the biopolymer chitosan as adjuvant. First, female and male mice (n = 4), in three subsequent experiments were vaccinated at Days 1 and 30 of the study, to determine the immune response profile and gonadal alterations due to immunization. The results demonstrated that the vaccine was able to elicit strong antibody responses against native GnRH hormone (P |
| Databáze: | OpenAIRE |
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