A retrospective study of induction chemotherapy with docetaxel, cisplatinum, and 5-fluorouracil followed by concurrent radiotherapy with cetuximab in locally advanced head and neck cancer
| Autor: | Robert O. Dillman, Russell Hafer, Marianne Plunkett, Minh Nguyen, Craig Cox, Annamarie Minion, Louis A. VanderMolen, Peter Chen, R. Matthew Carroll, Ralph Mackintosh, Brian S. Kim, Neil M. Barth, JinChu Huang |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Oncology medicine.medical_specialty medicine.medical_treatment Cetuximab Docetaxel Antibodies Monoclonal Humanized Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Prospective cohort study Aged Neoplasm Staging Retrospective Studies business.industry Head and neck cancer Antibodies Monoclonal Induction chemotherapy Retrospective cohort study Induction Chemotherapy medicine.disease Radiation therapy Treatment Outcome Otorhinolaryngology Head and Neck Neoplasms Fluorouracil Female Taxoids Radiotherapy Intensity-Modulated Cisplatin business medicine.drug |
| Zdroj: | American Journal of Otolaryngology. 33:93-97 |
| ISSN: | 0196-0709 |
| DOI: | 10.1016/j.amjoto.2011.02.004 |
| Popis: | Background The objective was to study the results of induction chemotherapy followed by external beam radiation therapy with concurrent cetuximab in the treatment of locally advanced head and neck cancer. Methods Seventeen patients with stage III or IV squamous cell carcinomas of the head and neck who received docetaxel, cisplatinum, and 5-fluorouracil followed by radiation therapy with concurrent cetuximab were retrospectively analyzed. All radiation was delivered with image-guided intensity-modulated radiation treatments. Primary end points analyzed were local control and overall survival. Results With a median follow-up of 17 months, the approximate 2-year local control was 85%, with overall survival being 91%. At time of last follow-up, only 1 death was observed, with the cause of death unknown. Two local failures were observed, and the patients were under active management for their recurrences at time of last follow-up. No distant metastatic failures were noted among the patients. Conclusions Induction chemotherapy with docetaxel, cisplatinum, and 5-fluorouracil followed by concurrent radiation with cetuximab provides for excellent locoregional control of disease. Future prospective studies can better establish the efficacy of this treatment regimen to current favored protocols. |
| Databáze: | OpenAIRE |
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