Pharmacokinetics and dose response after intravenous and subcutaneous administration of recombinant erythropoietin in patients on regular haemodialysis treatment or continuous ambulatory peritoneal dialysis
| Autor: | C. Jahn, M. T. Gottsauner-Wolf, Th.F. Meisl, W. Manker, Peter Balcke, U. Loibl, Felix Stockenhuber |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_specialty Anemia medicine.medical_treatment Injections Subcutaneous Urology Peritoneal dialysis Route of administration Pharmacokinetics Peritoneal Dialysis Continuous Ambulatory Renal Dialysis Albumins medicine Humans Erythropoietin Dose-Response Relationship Drug business.industry Continuous ambulatory peritoneal dialysis Preservatives Pharmaceutical Middle Aged medicine.disease Surgery Ambulatory Injections Intravenous Female Hemodialysis business medicine.drug |
| Zdroj: | Nephron. 59(3) |
| ISSN: | 1660-8151 |
| Popis: | The pharmacokinetics and dose response of recombinant human erythropoietin (rhEPO), administered intravenously and subcutaneously, were studied in chronic haemodialysis (HD) patients and in patients on chronic ambulatory peritoneal dialysis (CAPD). Furthermore, two products differing in the presence of albumin as preservative were compared. Although the pharmacokinetics differed after intravenous and subcutaneous administration, the dose response was the same. There is no statistically significant difference in the pharmacokinetics between the rhEPO in HD and CAPD, nor had the presence of albumin as preservative an influence on the pharmacokinetics. |
| Databáze: | OpenAIRE |
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