Medical Plants and Nutraceuticals for Amyloid-β Fibrillation Inhibition
| Autor: | Steffi Witter, Raivo Vilu, Ago Samoson, Raiker Witter |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Drug
Centella asiatica media_common.quotation_subject amyloid-β Withania somnifera Pharmacology Convolvulus pluricaulis Nutraceutical medicine Dementia Bacopa monnieri medical plants media_common Fibrillation Centella biology business.industry General Neuroscience biology.organism_classification medicine.disease Psychiatry and Mental health Clinical Psychology nutraceutical Geriatrics and Gerontology medicine.symptom business Alzheimer’s disease Research Article |
| Zdroj: | Journal of Alzheimer's Disease Reports |
| ISSN: | 2542-4823 |
| DOI: | 10.3233/adr-180066 |
| Popis: | Plaque formation due to amyloid-β oligomerization and fibrillation is a key issue for its deposition in the brains of dementia and Alzheimer’s disease patients. Related drugs preventing this peptide fibril accumulation bear the potential of considerable medical and social value. In this study, we performed in vitro fibrillation inhibition tests with eight different medical plant extracts and nutraceuticals using fluorescence spectroscopy. Successful inhibition of the following plant extracts and nutraceuticals were obtained: Withania somnifera, Centella asiatica, Bacopa monnieri, and Convolvulus pluricaulis, providing new drug candidates for the prevention and treatment of Alzheimer’s disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|