Sunscreens with the New MCE Filter Cover the Whole UV Spectrum: Improved UVA1 Photoprotection In Vitro and in a Randomized Controlled Trial
| Autor: | Xavier Marat, Romain de Dormael, Didier Candau, Françoise Bernerd, Philippe Bastien, Christelle Golebiewski, Julie Gizard, Emilie Planel, Claire Marionnet, Angelina Roudot, Carine Tornier |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
ITA°
individual typology angle Chemistry Uv spectrum KC keratinocyte Dermatology Absorption (skin) Comparative trial FC fold change In vitro Public health care law.invention MMP matrix metalloproteinase Randomized controlled trial In vivo law RL1-803 Photoprotection SPF sun-protection factor Original Article MCE Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate Biomedical engineering |
| Zdroj: | JID Innovations JID Innovations, Vol 2, Iss 1, Pp 100070-(2022) |
| ISSN: | 2667-0267 |
| Popis: | Background: UVA1 rays (340–400 nm) contribute to carcinogenesis, immunosuppression, hyperpigmentation, and aging. Current sunscreen formulas lack sufficient absorption in the 370–400 nm wavelengths range. Recently, a new UVA1 filter, Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate (MCE) exhibiting a peak of absorption at 385 nm, was approved by the Scientific Committee on Consumer Safety for use in sunscreen products. These studies evaluated, in a three-dimensional skin model and in vivo, the protection afforded by state-of-the-art sunscreen formulations enriched with MCE. Trial design: This study is a monocentric, double-blinded, randomized, and comparative trial. This study is registered at ClinicalTrials.gov with the identification number NCT04865094. Methods: The efficacy of sunscreens with MCE was compared with that of reference formulas. In a three-dimensional skin model, histology, protein, and gene expression were analyzed. In the clinical trial, pigmentation was analyzed in 19 volunteers using colorimetric measurements and visual scoring. Results: MCE addition in reference formulas enlarged the profile of absorption up to 400 nm; reduced UVA1-induced dermal and epidermal alterations at cellular, biochemical, and molecular levels; and decreased UVA1-induced pigmentation. Conclusions: Addition of MCE absorber in sunscreen formulations leads to full coverage of UV spectrum and improved UVA1 photoprotection. The data support benefits in the long term on sun-induced consequences, especially those related to public health care issues. |
| Databáze: | OpenAIRE |
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