Genetic polymorphisms of the SHBG gene can be the effect on SHBG and HDL-cholesterol levels in Coronary Heart Disease: a case–control study
| Autor: | Hulya Yilmaz-Aydogan, Beyhan Omer, Basak Akadam-Teker, Ozlem Kurnaz-Gomleksiz, Zehra Bugra |
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| Přispěvatelé: | Kurnaz-Gömleksiz, Özlem, Fakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Genetik Ana Bilim Dalı, Teker, Başak |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Genotype Coronary Disease Logistic regression Polymorphism Single Nucleotide Gene 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Sex hormone-binding globulin Gene Frequency Risk Factors Sex Hormone-Binding Globulin Internal medicine Genetics medicine Humans HDL-C SHBG Polymorphism Allele Molecular Biology biology Cholesterol business.industry Cholesterol HDL Case-control study General Medicine Middle Aged Coronary heart disease CHD 030104 developmental biology Endocrinology Haplotypes chemistry Case-Control Studies 030220 oncology & carcinogenesis biology.protein business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Molecular Biology Reports. 46:4259-4269 |
| ISSN: | 1573-4978 0301-4851 |
| DOI: | 10.1007/s11033-019-04880-x |
| Popis: | Aydogan, Hulya Yilmaz/0000-0002-8837-6664; Akadam Teker, Aysegul Basak/0000-0003-3618-0560 WOS:000478684300060 PubMed: 31111369 Sex hormone binding globulin (SHBG) level is positively associated with the high-density lipoprotein cholesterol (HDL-C) levels. The aim of this study was to investigate the effects of the SHBG gene variations (D356N, rs1799941, and P156L) on SHBG and HDL-C levels and Coronary Heart Disease (CHD) risk. The SHBG D356N (rs6259,G>A), P156L (rs6258,C>T), and rs1799941(G>A) polymorphisms were determined in 131 male CHD patients and 55 male controls by PCR-RFLP and real-time PCR techniques. SHGB levels were measured by Electro-chemiluminescence immunoassay (ECLIA). In the patients who had SHBG levels lower than threshold 35nmol/l value, the risk of being HDL-C levels lower than threshold 0.90mmol/l value was observed statistically significant (p=0.017; OR 2.522, 95% CI 1.170-5.438). The rs1799941 GG was associated with increased CHD risk when compared with the A allele carriers (GA+AA) (p=0.019, OR 2.222, 95% CI 1.130-4.371). In addition, the rs1799941 GG genotype and D356NN allele were associated with lower SHBG in the CHD group (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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