Liver X receptors, lipids and their reproductive secrets in the male
| Autor: | Fatim-Zorah El-Hajjaji, Silvère Baron, Aurélia Ouvrier, Jean-Marc A. Lobaccaro, Françoise Caira, Emilie Viennois, Joël R. Drevet, David H. Volle, Abdelkader Oumeddour, Fabrice Saez, Julie Dufour, Aurélien J. C. Pommier |
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| Přispěvatelé: | Génétique, Reproduction et Développement - Clermont Auvergne (GReD), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Clermont Université, Unité de Nutrition Humaine (UNH), Clermont Université-Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Recherche Agronomique (INRA), Génétique, Reproduction et Développement (GReD), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Předmět: |
Male
medicine.medical_specialty Biology Mice 03 medical and health sciences Liver X receptor beta 0302 clinical medicine Internal medicine Testis medicine polycyclic compounds Animals Humans [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology Liver X receptor Receptor Molecular Biology Liver X Receptors 030304 developmental biology Mice Knockout Epididymis 0303 health sciences Reproduction Prostate Liver X receptor alpha Lipid metabolism Orphan Nuclear Receptors Phenotype Lipids 3. Good health Endocrinology medicine.anatomical_structure Nuclear receptor 030220 oncology & carcinogenesis Molecular Medicine lipids (amino acids peptides and proteins) LXR |
| Zdroj: | Biochimica et Biophysica Acta-Molecular Basis of Disease Biochimica et Biophysica Acta-Molecular Basis of Disease, Elsevier, 2011, 1812 (8), pp.974. ⟨10.1016/j.bbadis.2011.02.004⟩ Biochimica et Biophysica Acta-Molecular Basis of Disease, 2011, 1812 (8), pp.974. ⟨10.1016/j.bbadis.2011.02.004⟩ |
| ISSN: | 0925-4439 |
| DOI: | 10.1016/j.bbadis.2011.02.004 |
| Popis: | Liver X receptor (LXR) α and LXRβ belong to the nuclear receptor superfamily. For many years, they have been called orphan receptors, as no natural ligand was identified. In the last decade, the LXR natural ligands have been shown to be oxysterols, molecules derived from cholesterol. While these nuclear receptors have been abundantly studied for their roles in the regulation of lipid metabolism, it appears that they also present crucial activities in reproductive organs such as testis and epididymis, as well as prostate. Phenotypic analyses of mice lacking LXRs ( lxr −/−) pointed out their physiological activities in the various cells and organs regulating reproductive functions. This review summarizes the impact of LXR-deficiency in male reproduction, highlighting the novel information coming from the phenotypic analyses of lxrα −/−, lxrβ −/− and lxrα;β −/− mice. This article is part of a Special Issue entitled: Translating nuclear receptor from health to disease. |
| Databáze: | OpenAIRE |
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