Do some tyrosine hydroxylase-immunoreactive neurons in the human ventrolateral arcuate nucleus and globus pallidus produce only L-dopa?
| Autor: | Kaoru Komori, Tetsuya Fujii, Ikuko Nagatsu |
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| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Tyrosine 3-Monooxygenase Dopamine Hypothalamus Dopamine beta-Hydroxylase Biology Medium spiny neuron Globus Pallidus Basal Ganglia Levodopa Arcuate nucleus Internal medicine Basal ganglia medicine Humans Neurons Tyrosine hydroxylase General Neuroscience Dopaminergic Arcuate Nucleus of Hypothalamus Infant Newborn Endocrinology Globus pallidus nervous system Aromatic-L-Amino-Acid Decarboxylases medicine.drug |
| Zdroj: | Neuroscience letters. 133(2) |
| ISSN: | 0304-3940 |
| Popis: | The presence of 'tyrosine hydroxylase (TH)-only'-immunoreactive (IR) neurons is reported for the first time in the human hypothalamic region and basa ganglia, using immunohistochemical technique. 'TH-only'-IR neurons were demonstrated in the ventrolateral part of the arcuate nucleus and medial segment of globus pallidus. These neurons lacked aromatic L-amino acid decarboxylase (AADC)-, dopamine-beta-hydroxylase (DBH)-, and dopamine (DA)-immunoreactivity. The above results suggest that these 'TH-only'-IR neurons are not dopaminergic, and possibly contain L-DOPA as an end-product. |
| Databáze: | OpenAIRE |
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