t(8;14;18): A 3-way chromosome translocation in two patients with Burkitt's lymphoma/leukemia
| Autor: | Karen Seiter, Delong Liu, Josif Shimonov, Tauseef Ahmed, Suneeta Primanneni, Yongrong Lai |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Cancer Research Short Communication Genes myc Chromosomal translocation lcsh:RC254-282 Translocation Genetic immune system diseases hemic and lymphatic diseases medicine Humans Gene Chromosomes Human Pair 14 Genes Immunoglobulin biology Remission Induction Karyotype Middle Aged lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Burkitt Lymphoma Combined Modality Therapy Molecular biology Genes bcl-2 Lymphoma Leukemia Oncology Karyotyping biology.protein Molecular Medicine Immunoglobulin heavy chain Female Antibody Chromosomes Human Pair 18 Immunoglobulin Heavy Chains Burkitt's lymphoma Chromosomes Human Pair 8 |
| Zdroj: | Molecular Cancer Molecular Cancer, Vol 6, Iss 1, p 35 (2007) |
| ISSN: | 1476-4598 |
| DOI: | 10.1186/1476-4598-6-35 |
| Popis: | Burkitt's lymphoma (BL) is a heterogeneous group of highly aggressive mature B-cell malignancies. It is characterized by a high rate of turnover of malignant cells and deregulation of the c-myc gene. It is typically associated with a t(8;14) translocation. Dual translocation of t(8;14) (c-myc) and t(14;18) (bcl-2) was reported to be associated with extremely poor prognosis. This study reports a novel t(8;14;18) triple translocation in two patients with Burkitt's lymphoma. |
| Databáze: | OpenAIRE |
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