feG-COOH blunts eosinophilic airway inflammation in a feline model of allergic asthma
| Autor: | Carol R. Reinero, Laura A. Nafe, Elizabeth K Schooley, Amy E. DeClue |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Allergy
Immunology Cell Count Nitric Oxide Poaceae medicine.disease_cause Placebo Interferon-gamma Allergen Hypersensitivity medicine Animals Anti-Asthmatic Agents Pharmacology Feline asthma Nitrates CATS medicine.diagnostic_test business.industry Proteins Pneumonia respiratory system Eosinophil medicine.disease Asthma respiratory tract diseases Eosinophils Phenotype Bronchoalveolar lavage medicine.anatomical_structure Cats Cytokines Interleukin-4 business Airway Bronchoalveolar Lavage Fluid Oligopeptides |
| Zdroj: | Inflammation Research. 58:457-462 |
| ISSN: | 1420-908X 1023-3830 |
| DOI: | 10.1007/s00011-009-0010-1 |
| Popis: | This study investigated if feG-COOH would decrease allergen-induced airway inflammation.Seven adult cats sensitised to Bermuda grass allergen (BGA) to induce an asthmatic phenotype.Cats were randomized to receive either feG-COOH (1 mg/kg, PO) or placebo (saline 1 ml, PO) immediately prior to BGA aerosol challenge in a cross-over design.Bronchoalveolar lavage fluid (BALF) was collected and airway inflammatory response assessed via inflammatory cell number and type; IL-4, IFN-gamma and nitric oxide metabolite concentrations. A paired t test was used to compare parameters with a P0.05 considered significant.The BALF eosinophil percentage was significantly lower in asthmatic cats treated with feG compared with placebo (placebo, 35.3 +/- 12.2%; feG, 22.4 +/- 8.6%; P = 0.002). Treatment with feG did not result in a significant change in any other parameter measured.These data indicate that a single dose of feG-COOH partially attenuates eosinophilic airway inflammation in experimental feline asthma. |
| Databáze: | OpenAIRE |
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