Naturally occurring N 6 -substituted adenosines (cytokinin ribosides) are in vitro inhibitors of platelet aggregation: An in silico evaluation of their interaction with the P2Y 12 receptor
| Autor: | Cristina Razzari, Giulio Vistoli, Enzo Santaniello, Elena M. Faioni, Andrea Brizzolari |
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| Rok vydání: | 2014 |
| Předmět: |
Blood Platelets
Adenosine Cytokinins Platelet Aggregation In silico Clinical Biochemistry Pharmaceutical Science In Vitro Techniques Biochemistry P2Y12 Plant Growth Regulators Drug Discovery Purinergic P1 Receptor Agonists medicine Humans Homology modeling Receptor Molecular Biology IC50 Chemistry Organic Chemistry Receptors Purinergic P2Y12 In vitro Adenosine Diphosphate Docking (molecular) Molecular Medicine Ribonucleosides Platelet Aggregation Inhibitors medicine.drug |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 24:5652-5655 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2014.10.080 |
| Popis: | A few naturally occurring N(6)-substituted adenosine derivatives (cytokinin ribosides) were investigated as inhibitors of platelet aggregation induced in vitro by collagen and their activity range was demonstrated (IC50: 6.77-141 μM). A docking study suggests that anti-aggregation activity of these compounds could involve an interaction with the P2Y12 receptor binding site. |
| Databáze: | OpenAIRE |
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