Neuroendocrine tumors producing calcitonin: characteristics, prognosis and potential interest of calcitonin monitoring during follow-up
| Autor: | Cécile Nozières, Karim Chikh, Françoise Borson-Chazot, Bernard Goichot, Laurence Chardon, Valérie Hervieu, Thomas Walter, Catherine Lombard-Bohas |
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| Přispěvatelé: | Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Endocrinology Diabetes and Metabolism Gastrointestinal Neoplasms/pathology/*secretion/therapy [SDV]Life Sciences [q-bio] Neuroendocrine tumors Cohort Studies 0302 clinical medicine Endocrinology Chromogranin A/blood 80 and over Medicine Gastrointestinal Neoplasms Malignant Carcinoid Syndrome Aged 80 and over Pancreatic Neoplasms/pathology/*secretion/therapy biology Bronchial Neoplasms Chromogranin A Medullary thyroid cancer General Medicine Middle Aged Prognosis Immunohistochemistry 3. Good health Neuroendocrine Tumors 030220 oncology & carcinogenesis Female Carcinoid syndrome Calcitonin Adult medicine.medical_specialty 030209 endocrinology & metabolism 03 medical and health sciences Internal medicine Humans Retrospective Studies Aged Proportional Hazards Models Bronchial Neoplasms/pathology/*secretion/therapy business.industry Malignant Carcinoid Syndrome/blood Retrospective cohort study Neuroendocrine Tumors/pathology/*secretion/therapy medicine.disease Pancreatic Neoplasms Calcitonin/blood/*secretion biology.protein Neoplasm Grading business |
| Zdroj: | European Journal of Endocrinology European Journal of Endocrinology, BioScientifica, 2016, 174 (3), pp.335-41. ⟨10.1530/EJE-15-0917⟩ |
| ISSN: | 0804-4643 1479-683X |
| DOI: | 10.1530/EJE-15-0917⟩ |
| Popis: | ObjectivesInappropriate calcitonin (CT) release, a major feature of medullary thyroid cancer (MTC), may occur in neuroendocrine tumors (NETs). The aims of this retrospective study were to assess i) the characteristics and prognosis of CT-producing NETs, and ii) the value of CT monitoring during follow-up.MethodsAll patients with NETs in whom serum CT was assayed between 2010 and 2012 were included. MTCs were excluded. Clinical, biological, and histological characteristics were studied.ResultsTwenty-one (12%) of 176 patients in whom serum CT was systematically assayed had concentrations >100 ng/l, with tumours predominantly of bronchial or pancreatic origin (PP=0.0006). Poor prognosis was linked to high CT levels, poor differentiation, and grade 3. In a total group of 24 patients with serum CT >100 ng/l, symptoms potentially attributable to CT were recorded in eight, with occasional overlap with the carcinoid syndrome among other secretory syndromes. Immunohistochemistry could be performed in six tumor specimens, CT being detected in five. In 11 patients with five or more successive CT assays, hormone levels were fairly well correlated with clinical courses.ConclusionSerum CT levels may be raised in some patients with NETs, especially from foregut origin, and of high grade. The suggested value of CT monitoring during follow-up must be confirmed in further studies. |
| Databáze: | OpenAIRE |
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