The effect of inflammatory factors and their inhibitors on the hematopoietic stem cells fate
| Autor: | Majid Ghanavat, Sahar Najafi, Zahra Gatavizadeh, Najmaldin Saki, S. Shahrabi |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment Inflammation Biology Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Bone Marrow medicine Animals Homeostasis Humans Cell Lineage Progenitor cell Myelopoiesis Hematopoietic stem cell Cell Differentiation Cell Biology General Medicine Hematopoietic Stem Cells Haematopoiesis 030104 developmental biology medicine.anatomical_structure Cytokine 030220 oncology & carcinogenesis Cancer research Cytokines Bone marrow Stem cell medicine.symptom Signal Transduction |
| Zdroj: | Cell biology internationalREFERENCES. 45(5) |
| ISSN: | 1095-8355 |
| Popis: | Inflammatory cytokines exert different effects on hematopoietic stem cells (HSCs), lead to the development of various cell lineages in bone marrow (BM) and are thus a differentiation axis for HSCs. The content used in this article has been obtained by searching PubMed database and Google Scholar search engine of English-language articles (1995-2020) using "Hematopoietic stem cell ","Inflammatory cytokine", "Homeostasis" and "Myelopoiesis ". Inflammatory cytokines are involved in the differentiation and proliferation of hematopoietic progenitors to compensate for cellular death due to inflammation. Since each of these cytokines differentiates HSCs into a specific cell line, the difference in the effect of these cytokines on the fate of HSC progenitors can be predicted. Inhibitors of these cytokines can also control the inflammatory process as well as the cells involved in leukemic conditions. In general, inflammatory signaling can specify the dominant cell line in BM to counteract inflammation and leukemic condition via stimulating or inhibiting hematopoietic progenitors. Therefore, detection of the effects of inflammatory cytokines on the differentiation of HSCs can be an appropriate approach to check inflammatory and leukemic conditions and the suppression of these cytokines by their inhibitors allows for control of homeostasis in stressful conditions. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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