Autoimmune hepatitis and IgG4-related disease
| Autor: | Tomohiro Watanabe, Hobyung Chung, Masatoshi Kudo, Kosuke Minaga |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Plasma Cells Autoimmune hepatitis Disease Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine parasitic diseases Medicine Humans skin and connective tissue diseases IgG4-related disease IgG4-associated autoimmune hepatitis Autoimmune disease IgG4 integumentary system business.industry Bile duct fungi Minireviews General Medicine medicine.disease digestive system diseases Review article Hepatitis Autoimmune medicine.anatomical_structure Liver 030220 oncology & carcinogenesis Immunoglobulin G 030211 gastroenterology & hepatology Immunoglobulin G4-Related Disease business Pancreas Infiltration (medical) |
| Zdroj: | World Journal of Gastroenterology |
| ISSN: | 2219-2840 1007-9327 |
| Popis: | IgG4-related disease (IgG4-RD) is a chronic-fibroinflammatory disorder affecting a wide range of organs. Elevation of serum IgG4 concentrations and abundant infiltration of IgG4-expressing plasma cells are key diagnostic features of this autoimmune disease. Although common organ involvement of IgG4-RD includes the salivary glands, pancreas, and bile duct, hepatic involvement is less well established. Recently, five studies identified a subtype of autoimmune hepatitis (AIH), called IgG4-associated AIH (IgG4-AIH). IgG4-AIH is diagnosed based on significant accumulation of IgG4-expressing plasmacytes in the liver in patients who met the diagnostic criteria for classical AIH. Although four of the five reports regarded IgG4-AIH based on hepatic accumulation of IgG4-positive cells alone, one report diagnosed IgG4-AIH based on both hepatic accumulation of IgG4-positive cells and elevated serum concentrations of IgG4. IgG4-AIH diagnosed based on the latter criteria may be a hepatic manifestation of IgG4-RD whereas IgG4-AIH diagnosed based on the former criteria may be a subtype of AIH. In this review article, we summarize and discuss clinicopathological features of IgG4-AIH. |
| Databáze: | OpenAIRE |
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