Treatment of Erectile Dysfunction with Pycnogenol and L-arginine
| Autor: | V Nikolova, R Stanislavov |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Time Factors Arginine Sexual Behavior medicine.medical_treatment Administration Oral Nitric oxide chemistry.chemical_compound Pharmacotherapy Erectile Dysfunction Smooth muscle Oral administration Humans Medicine Flavonoids Chemotherapy Plant Extracts business.industry Penile Erection Middle Aged medicine.disease Clinical Psychology Treatment Outcome Erectile dysfunction chemistry Patient Satisfaction Anesthesia Drug Therapy Combination Nitric Oxide Synthase business Sexual function Platelet Aggregation Inhibitors Muscle Contraction |
| Zdroj: | Journal of Sex & Marital Therapy. 29:207-213 |
| ISSN: | 1521-0715 0092-623X |
| DOI: | 10.1080/00926230390155104 |
| Popis: | Penile erection requires the relaxation of the cavernous smooth muscle, which is triggered by nitric oxide (NO). We investigated the possibility of overcoming erectile dysfunction (ED) by increasing the amounts of endogenous NO. For this purpose, we orally administered Pycnogenol, because it is known to increase production of NO by nitric oxide syntase together with L-arginine as substrate for this enzyme. The study included 40 men, aged 25-45 years, without confirmed organic erectile dysfunction. Throughout the 3-month trial period, patients received 3 ampoules Sargenor a day, a drinkable solution of the dipeptide arginyl aspartate (equivalent to 1.7 g L-arginine per day). During the second month, patients were additionally supplemented with 40 mg Pycnogenol two times per day; during the third month, the daily dosage was increased to three 40-mg Pycnogenol tablets. We obtained a sexual function questionnaire and a sexual activity diary from each patient. After 1 month of treatment with L-arginine, a statistically nonsignificant number of 2 patients (5%) experienced a normal erection. Treatment with a combination of L-arginine and Pycnogenol for the following month increased the number of men with restored sexual ability to 80%. Finally, after the third month of treatment, 92.5% of the men experienced a normal erection. We conclude that oral administration of L-arginine in combination with Pycnogenol causes a significant improvement in sexual function in men with ED without any side effects. |
| Databáze: | OpenAIRE |
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