Immunotherapy with internally inactivated virus loaded dendritic cells boosts cellular immunity but does not affect feline immunodeficiency virus infection course

Autor:	Francesca Tarabella, Leonia Bozzacco, Mauro Bendinelli, Mauro Pistello, Antonio Merico, Luca Ceccherini-Nelli, Paola Mazzetti, Donatella Matteucci, Giulia Freer, Enrica Ricci
Jazyk:	angličtina
Rok vydání:	2008
Předmět:	CD4-Positive T-Lymphocytes lcsh:Immunologic diseases. Allergy Feline immunodeficiency virus Cellular immunity Feline Immunodeficiency Virus medicine.medical_treatment animal diseases viruses Short Report Immunodeficiency Virus Feline Virus Human Immunodeficiency Virus Imiquimod Proviral Load Simian Immunodeficiency Virus Infection Immunity Feline Acquired Immunodeficiency Syndrome Virology medicine Animals Cell Proliferation Immunity Cellular biology Viral Vaccine virus diseases Viral Vaccines Dendritic Cells Immunotherapy Viral Load biochemical phenomena metabolism and nutrition biology.organism_classification Infectious Diseases Vaccines Inactivated Immunology Cats lcsh:RC581-607 Viral load
Zdroj:	Retrovirology, Vol 5, Iss 1, p 33 (2008) Retrovirology
ISSN:	1742-4690
Popis:	Immunotherapy of feline immunodeficiency virus (FIV)-infected cats with monocyte-derived dendritic cells (MDCs) loaded with aldrithiol-2 (AT2)-inactivated homologous FIV was performed. Although FIV-specific lymphoproliferative responses were markedly increased, viral loads and CD4+ T cell depletion were unaffected, thus indicating that boosting antiviral cell-mediated immunity may not suffice to modify infection course appreciably.
Databáze:	OpenAIRE
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