Flow chamber and microfluidic approaches for measuring thrombus formation in genetic bleeding disorders
| Autor: | Keith B. Neeves, Marcus Lehmann, Rogier M. Schoeman |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Platelet adhesion medicine.medical_treatment Microfluidics Hemorrhage 030204 cardiovascular system & hematology Article 03 medical and health sciences 0302 clinical medicine Lab-On-A-Chip Devices Fibrinolysis medicine Animals Humans Thrombus business.industry Genetic Diseases Inborn Thrombosis Hematology General Medicine Microfluidic Analytical Techniques medicine.disease Thrombosis Research 030104 developmental biology Flow (mathematics) Hemostasis Integrated optics business Biomedical engineering |
| Popis: | Platelet adhesion and aggregation, coagulation, fibrin formation, and fibrinolysis are regulated by the forces and flows imposed by blood at the site of a vascular injury. Flow chambers designed to observe these events are an indispensable part of doing hemostasis and thrombosis research, especially with human blood. Microfluidic methods have provided the flexibility to design flow chambers with complex geometries and features that more closely mimic the anatomy and physiology of blood vessels. Additionally, microfluidic systems with integrated optics and/or pressure sensors and on-board signal processing could transform what have been primarily research tools into clinical assays. Here, we describe a historical review of how flow-based approaches have informed biophysical mechanisms in genetic bleeding disorders, challenges and potential solutions for developing models of bleeding in vitro, and outstanding issues that need to be addressed prior to their use in clinical settings. |
| Databáze: | OpenAIRE |
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