Pulmonary fat embolism and related effects during femoral intramedullary surgery: An experimental study in dogs
| Autor: | Qing Song, Jun Ji, Guoqiang Zhang, Feihu Zhou, Zhiyong Peng, Yan Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Cancer Research
medicine.medical_specialty Mean arterial pressure Medullary cavity business.industry Central venous pressure Hemodynamics General Medicine Articles respiratory system hemodynamics law.invention Surgery Intramedullary rod Immunology and Microbiology (miscellaneous) extravascular lung water law pulmonary fat embolism Heart rate cytokine Medicine Arterial blood business Pulmonary wedge pressure |
| Zdroj: | Experimental and Therapeutic Medicine |
| ISSN: | 1792-1015 1792-0981 |
| Popis: | The aim of the present study was to develop an animal model of pulmonary fat embolism (PFE) caused by femoral intramedullary procedures, and to investigate the initial changes in the hemodynamics, cytokines and risk factors of PFE. Sixteen dogs were randomly divided into two groups: Group A (intramedullary reaming and bone cement injection, n=8) and Group B (surgical approach without opening the medullary cavity, n=8). The hemodynamics, arterial blood gases and relevant cytokines were evaluated, and the lungs were examined using Oil Red O staining. In the animals of Group A, the heart rate, central venous pressure, mean pulmonary arterial pressure, pulmonary capillary wedge pressure and extravascular lung water (EVLW) were increased compared with the baseline levels, while the mean arterial pressure was decreased immediately following the reaming and bone cement infusion (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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