High Levels of Dietary Carnosine Are Associated with Increased Concentrations of Carnosine and Histidine in Rat Soleus Muscle
| Autor: | Gilbert A. Boissonneault, Ching K. Chow, Geza Bruckner, L. Michele Maynard |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Vitamin medicine.medical_specialty medicine.medical_treatment Medicine (miscellaneous) Carnosine Dietary vitamin Antioxidants Rats Sprague-Dawley Random Allocation chemistry.chemical_compound Internal medicine medicine Animals Vitamin E Histidine Vitamin E Deficiency Muscle Skeletal Soleus muscle Nutrition and Dietetics Dose-Response Relationship Drug Nutritional status Rats Muscle Fibers Slow-Twitch Endocrinology Biochemistry chemistry Muscle Fibers Fast-Twitch Lateral gastrocnemius |
| Zdroj: | The Journal of Nutrition. 131:287-290 |
| ISSN: | 0022-3166 |
| DOI: | 10.1093/jn/131.2.287 |
| Popis: | The aims of this investigation were to: 1) determine the effect of a moderately high dose of carnosine on muscle concentrations of carnosine, histidine and vitamin E at deficient, minimally adequate and sufficient levels of dietary vitamin E and 2) compare the effects of moderately high and pharmacological doses of carnosine on muscle concentrations of carnosine, histidine and vitamin E when dietary vitamin E is minimally adequate. Muscle concentrations of carnosine, histidine and vitamin E were measured in the lateral gastrocnemius and red and white vastus lateralis; carnosine and histidine concentrations were also measured in soleus muscle. Male Sprague-Dawley rats (n = 12/group) were fed a basal vitamin E-deficient diet supplemented with either 0, 0.001 or 0.01% vitamin E and 0, 0.1 or 1.8% carnosine. After 8 wk, 1.8% carnosine resulted in significant fivefold increases in carnosine and twofold increases in histidine in the soleus muscle (P < or = 0.05). Muscle vitamin E concentrations were not significantly affected by dietary carnosine. Thus, very high levels of dietary carnosine are associated with increases in carnosine and histidine concentrations in rat soleus muscle. |
| Databáze: | OpenAIRE |
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