Seasonal Changes in Brain Serotonin Transporter Binding in Short Serotonin Transporter Linked Polymorphic Region-Allele Carriers but Not in Long-Allele Homozygotes
| Autor: | Klaus K. Holst, Tine E. Arentzen, Finn Årup Nielsen, Lisbeth Marner, Szabolcs Lehel, Jan Kalbitzer, Gitte M. Knudsen, David Erritzoe, Terry L. Jernigan |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Periodicity medicine.medical_specialty Genotype Population DASB White People chemistry.chemical_compound Gene Frequency Internal medicine mental disorders Image Processing Computer-Assisted medicine Humans Allele Radionuclide Imaging education Allele frequency Alleles Biological Psychiatry Serotonin transporter Serotonin Plasma Membrane Transport Proteins Genetics Brain Mapping education.field_of_study Polymorphism Genetic biology Putamen Brain Middle Aged Magnetic Resonance Imaging Endocrinology nervous system chemistry 5-HTTLPR biology.protein Female Serotonin |
| Zdroj: | Biological Psychiatry. 67:1033-1039 |
| ISSN: | 0006-3223 |
| DOI: | 10.1016/j.biopsych.2009.11.027 |
| Popis: | Background A polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) has been associated with seasonality both in patients with seasonal affective disorder and in the general population. Method We used in vivo molecular imaging to measure cerebral serotonin transporter (5-HTT) binding in 57 healthy Scandinavians and related the outcome to season of the year and to the 5-HTTLPR carrier status. Results We found that the number of daylight minutes at the time of scanning correlated negatively with 5-HTT binding in the putamen and the caudate, with a similar tendency in the thalamus, whereas this association was not observed for the midbrain. Furthermore, in the putamen, an anatomic region with relatively dense serotonin innervation, we found a significant gene × daylight effect, such that there was a negative correlation between 5-HTT binding and daylight minutes in carriers of the short 5-HTTLPR allele but not in homozygote carriers of the long allele. Conclusions Our findings are in line with S-carriers having an increased response in neural circuits involved in emotional processing to stressful environmental stimuli but here demonstrated as a endophenotype with dynamic changes in serotonin reuptake. |
| Databáze: | OpenAIRE |
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