Higher Body Mass Index Is Associated With Greater Proportions of Effector CD8+ T Cells Expressing CD57 in Women Living With HIV
| Autor: | Sheri D. Weiser, Peter W. Hunt, Lila A. Sheira, Adebola Adedimeji, Mardge H. Cohen, Edward A. Frongillo, Daniel Merenstein, Reid Mja, Deborah R. Gustafson, Alan L. Landay, Phyllis C. Tien, Eryka L. Wentz, Sanjiv M. Baxi |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
0301 basic medicine medicine.medical_specialty Waist Anti-HIV Agents HIV Infections CD8-Positive T-Lymphocytes Biology Article Body Mass Index 03 medical and health sciences CD57 Antigens 0302 clinical medicine T-Lymphocyte Subsets Antiretroviral Therapy Highly Active Internal medicine medicine Humans Cytotoxic T cell Pharmacology (medical) 030212 general & internal medicine CD28 Middle Aged Viral Load United States Confidence interval Phenotype 030104 developmental biology Infectious Diseases Socioeconomic Factors Immunology Cohort HIV-1 Women's Health Female Body mass index Viral load CD8 |
| Zdroj: | JAIDS Journal of Acquired Immune Deficiency Syndromes. 75:e132-e141 |
| ISSN: | 1525-4135 |
| Popis: | BACKGROUND A low proportion of CD28CD8 T cells that express CD57 is associated with increased mortality in HIV infection. The effect of increasing body mass index (BMI) changes in the proportion of CD57CD28CD8 T cells among HIV-infected individuals on antiretroviral therapy is unknown. SETTING In a US cohort of HIV-infected women, we evaluated associations of BMI and waist circumference with 3 distinct CD8 T cell phenotypes: % CD28CD57CD8 T cells, % CD57 of CD28CD8 T cells, and % CD28 of all CD8 T cells. METHODS Multivariable linear regression analysis was used to estimate beta coefficients for each of 3 T-cell phenotypes. Covariates included HIV parameters (current and nadir CD4, current viral load), demographics (age, race, income, and study site), and lifestyle (tobacco and alcohol use) factors. RESULTS Of 225 participants, the median age was 46 years and 50% were obese (BMI >30 m/kg). Greater BMI and waist circumference were both associated with higher % CD28CD57CD8 T cells and % CD57 of all CD28CD8 T cells in multivariable analysis, including adjustment for HIV viral load (all P < 0.05). The association between greater BMI and the overall proportion of CD28 CD8 cells in fully adjusted models (0.078, 95% confidence interval: -0.053 to 0.209) was not significant. CONCLUSIONS In this analysis, greater BMI and waist circumference are associated with greater expression of CD57 on CD28CD8 T cells and a greater proportion of CD57CD28 CD8 T cells. These findings may indicate that increasing BMI is immunologically protective in HIV-infected women. Future research is needed to understand the prognostic importance of these associations on clinical outcomes. |
| Databáze: | OpenAIRE |
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