Specimen origin, type and testing laboratory are linked to longer turnaround times for HIV viral load testing in Malawi

Autor: Reuben Mwenda, Peter A. Minchella, Abdoulaye Dieng Sarr, Geoffrey Chipungu, Hammad Ali, John N. Nkengasong, Daniel E. Singer, Andrea A. Kim
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Gerontology
RNA viruses
Malawi
Research Facilities
Time Factors
Epidemiology
lcsh:Medicine
HIV Infections
Logistic regression
Pathology and Laboratory Medicine
Turnaround time
Geographical Locations
0302 clinical medicine
Mathematical and Statistical Techniques
Immunodeficiency Viruses
Interquartile range
Medicine and Health Sciences
Medicine
Public and Occupational Health
030212 general & internal medicine
lcsh:Science
health care economics and organizations
Multidisciplinary
Viral Load
Vaccination and Immunization
Specimen collection
Molecular Diagnostic Techniques
HIV epidemiology
Medical Microbiology
Viral Pathogens
Physical Sciences
Viruses
Regression Analysis
Pathogens
Research Laboratories
Viral load
Statistics (Mathematics)
Research Article
medicine.medical_specialty
030231 tropical medicine
Immunology
Antiretroviral Therapy
Research and Analysis Methods
Microbiology
Odds
03 medical and health sciences
Antiviral Therapy
Virology
Retroviruses
Confidence Intervals
Humans
Statistical Methods
Microbial Pathogens
business.industry
lcsh:R
Lentivirus
Organisms
Biology and Life Sciences
HIV
Infant
Odds ratio
Confidence interval
Emergency medicine
People and Places
Africa
HIV-1
lcsh:Q
Preventive Medicine
business
Viral Transmission and Infection
Mathematics
Government Laboratories
Zdroj: PLoS ONE
PLoS ONE, Vol 12, Iss 2, p e0173009 (2017)
ISSN: 1932-6203
Popis: Background Efforts to reach UNAIDS’ treatment and viral suppression targets have increased demand for viral load (VL) testing and strained existing laboratory networks, affecting turnaround time. Longer VL turnaround times delay both initiation of formal adherence counseling and switches to second-line therapy for persons failing treatment and contribute to poorer health outcomes. Methods We utilized descriptive statistics and logistic regression to analyze VL testing data collected in Malawi between January 2013 and March 2016. The primary outcomes assessed were greater-than-median pretest phase turnaround time (days elapsed from specimen collection to receipt at the laboratory) and greater-than-median test phase turnaround time (days from receipt to testing). Results The median number of days between specimen collection and testing increased 3-fold between 2013 (8 days, interquartile range (IQR) = 6–16) and 2015 (24, IQR = 13–39) (p
Databáze: OpenAIRE