Physical activity and renal function in the Italian kidney transplant population

Autor: Massimo Cardillo, Maria Laura Angelini, Letizia Lombardini, Alessandro Nanni Costa, Lucia Masiero, Lia Bellis, Valentina Totti, Alessandra Spazzoli, Francesca Puoti, Gianluigi Sella, G. Mosconi
Rok vydání: 2020
Předmět:
Male
Databases
Factual
030232 urology & nephrology
physical activity
030204 cardiovascular system & hematology
Kidney
lcsh:RC870-923
Critical Care and Intensive Care Medicine
Kidney transplant
0302 clinical medicine
sedentary lifestyle
propensity score match
Medicine
education.field_of_study
exercise
General Medicine
Middle Aged
surgical procedures
operative
Italy
Nephrology
Female
Research Article
Glomerular Filtration Rate
Adult
medicine.medical_specialty
Adolescent
Population
Physical activity
Renal function
Young Adult
03 medical and health sciences
Renal Dialysis
Internal medicine
Humans
Obesity
Propensity Score
education
Aged
Sedentary lifestyle
business.industry
renal function
mixed-regression-analysis
lcsh:Diseases of the genitourinary system. Urology
Kidney Transplantation
Logistic Models
Multivariate Analysis
egfr
Clinical Study
Linear Models
Sedentary Behavior
kidney transplant recipients
business
Zdroj: Renal Failure, Vol 42, Iss 1, Pp 1192-1204 (2020)
Renal Failure
article-version (VoR) Version of Record
ISSN: 1525-6049
0886-022X
DOI: 10.1080/0886022x.2020.1847723
Popis: Background The well-documented benefits of physical activity (PA) are still poorly characterized in long-term kidney transplant outcome. This study analyzed the impact over a 10-year follow-up of PA on graft function in Italian kidney transplant recipients (KTRs). Methods Since 2002, the Italian Transplant-Information-System collected donor and recipient baseline and transplant-related parameters in KTRs. In 2015, ‘penchant for PA’ (PA ≥ 30-min, 5 times/week) was added. Stable patients aged ≥18 years at the time of first-transplantation were eligible. KTRs with at least 10-year follow-up were also analyzed. Mixed-effect regression models were used to compare eGFR changes over time in active versus non-active patients. Results PA information was available for 6,055 KTRs (active 51.6%, non-active 48.4%). Lower penchant for PA was found in overweight and obese patients (OR = 0.84; OR = 0.48, respectively), in those with longer dialysis vintage (OR = 0.98 every year of dialysis), and older age at transplant. Male subjects showed greater penchant for PA (OR = 1.25). A slower decline of eGFR over time was observed in active KTRs compared to non-active, and this finding was confirmed in the subgroup with at least 10-year follow-up (n = 2,060). After applying the propensity score matching to reduce confounding factors, mixed-effect regression models corroborated such better long-term trend of graft function preservation in active KTRs. Conclusions Penchant for PA is more frequent among male and younger KTRs. Moreover, in our group of Italian KTRs, active patients revealed higher eGFR values and preserved kidney function over time, up to 10-years of follow-up.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje